Lack of Association between Epidermal Growth Factor or Its
Receptor and Reflux Esophagitis, Barrett’s Esophagus, and
Esophageal Adenocarcinoma: A Case-Control Study

Přehled o publikaci

J 2022

Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study

DEISSOVÁ, Tereza; Michaela CVANOVÁ; Zdeněk KALA; Zuzana JIRASKOVA ZAKOSTELSKA; Jiří DOLINA et al.

Basic information

Original name

Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study

Authors

Edition

Disease Markers, LONDON, HINDAWI LTD, 2022, 0278-0240

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Marked to be transferred to RIV

Yes

RIV identification code

RIV/00216224:14110/22:00126886

Organization

Lékařská fakulta – Repository – Repository

Keywords in English

Epidermal Growth Factor; Reflux Esophagitis; Barrett's Esophagus; Esophageal Adenocarcinoma

Links

EF17_043/0009632, research and development project. NU20-03-00126, research and development project. 857560, interní kód Repo. RECETOX RI, large research infrastructures.

Changed: 14/6/2025 00:50, RNDr. Daniel Jakubík

Abstract

In the original language

gt;A EGFR (rs2227983) polymorphisms using the TaqMan quantitative polymerase chain reaction (qPCR). In random subgroups, the EGF and EGFR mRNA expressions were analyzed by reverse transcription qPCR in esophageal tissue with and without endoscopically visible pathological changes; and the EGF plasma levels were determined by enzyme-linked immunosorbent assay. None of the genotyped SNPs nor EGF-EGFR genotype interactions were associated with RE, BE, or EAC development (). Moreover, mRNA expression of neither EGF nor EGFR differed between samples of the esophageal tissue with and without endoscopically visible pathology () nor between samples from patients with different diagnoses, i.e., RE, BE, or EAC (). Nevertheless, the lower EGF mRNA expression in carriers of combined genotypes AA +61 EGF (rs4444903) and GG +142285 EGFR (rs2227983; ) suggests a possible direct/indirect effect of EGF-EGFR gene interactions on EGF gene expression. In conclusion, EGF and EGFR gene variants and their mRNA/protein expression were not associated with RE, BE or EAC development in the Central European population.

Files attached

https://is.muni.cz/publication/2224704/2224704.pdf

Cite

DEISSOVÁ, Tereza; Michaela CVANOVÁ; Zdeněk KALA; Zuzana JIRASKOVA ZAKOSTELSKA; Jiří DOLINA; Lumír KUNOVSKÝ; Radek KROUPA; Zdeněk PAVLOVSKÝ; Břetislav LIPOVÝ; Zdeněk DANĚK; Lydie IZAKOVIČOVÁ HOLLÁ; Ondrej URBAN; Vit NAVRATIL; Robert LISCHKE; Tomas HARUSTIAK; Tomáš GROLICH; Vladimír PROCHÁZKA; Ondřej SLABÝ and Petra BOŘILOVÁ LINHARTOVÁ. Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study. Disease Markers. LONDON: HINDAWI LTD, 2022, vol. 2022, August, p. 1-13. ISSN 0278-0240. Available from: https://doi.org/10.1155/2022/8790748.

@article{75606,
   author = {Deissová, Tereza and Cvanová, Michaela and Kala, Zdeněk and Jiraskova Zakostelska, Zuzana and Dolina, Jiří and Kunovský, Lumír and Kroupa, Radek and Pavlovský, Zdeněk and Lipový, Břetislav and Daněk, Zdeněk and Izakovičová Hollá, Lydie and Urban, Ondrej and Navratil, Vit and Lischke, Robert and Harustiak, Tomas and Grolich, Tomáš and Procházka, Vladimír and Slabý, Ondřej and Bořilová Linhartová, Petra},
   article_location = {LONDON},
   article_number = {August},
   doi = {https://doi.org/10.1155/2022/8790748},
   keywords = {Epidermal Growth Factor; Reflux Esophagitis; Barrett's Esophagus; Esophageal Adenocarcinoma},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study},
   url = {https://www.hindawi.com/journals/dm/2022/8790748/},
   volume = {2022},
   year = {2022}
}

TY  - JOUR
ID  - 75606
AU  - Deissová, Tereza - Cvanová, Michaela - Kala, Zdeněk - Jiraskova Zakostelska, Zuzana - Dolina, Jiří - Kunovský, Lumír - Kroupa, Radek - Pavlovský, Zdeněk - Lipový, Břetislav - Daněk, Zdeněk - Izakovičová Hollá, Lydie - Urban, Ondrej - Navratil, Vit - Lischke, Robert - Harustiak, Tomas - Grolich, Tomáš - Procházka, Vladimír - Slabý, Ondřej - Bořilová Linhartová, Petra
PY  - 2022
TI  - Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study
JF  - Disease Markers
VL  - 2022
IS  - August
SP  - 1-13
EP  - 1-13
PB  - HINDAWI LTD
SN  - 0278-0240
KW  - Epidermal Growth Factor
KW  - Reflux Esophagitis
KW  - Barrett's Esophagus
KW  - Esophageal Adenocarcinoma
UR  - https://www.hindawi.com/journals/dm/2022/8790748/
N2  - gt;A EGFR (rs2227983) polymorphisms using the TaqMan quantitative polymerase chain reaction (qPCR). In random subgroups, the EGF and EGFR mRNA expressions were analyzed by reverse transcription qPCR in esophageal tissue with and without endoscopically visible pathological changes; and the EGF plasma levels were determined by enzyme-linked immunosorbent assay. None of the genotyped SNPs nor EGF-EGFR genotype interactions were associated with RE, BE, or EAC development (). Moreover, mRNA expression of neither EGF nor EGFR differed between samples of the esophageal tissue with and without endoscopically visible pathology () nor between samples from patients with different diagnoses, i.e., RE, BE, or EAC (). Nevertheless, the lower EGF mRNA expression in carriers of combined genotypes AA +61 EGF (rs4444903) and GG +142285 EGFR (rs2227983; ) suggests a possible direct/indirect effect of EGF-EGFR gene interactions on EGF gene expression. In conclusion, EGF and EGFR gene variants and their mRNA/protein expression were not associated with RE, BE or EAC development in the Central European population.
ER  -

DEISSOVÁ, Tereza; Michaela CVANOVÁ; Zdeněk KALA; Zuzana JIRASKOVA ZAKOSTELSKA; Jiří DOLINA; Lumír KUNOVSKÝ; Radek KROUPA; Zdeněk PAVLOVSKÝ; Břetislav LIPOVÝ; Zdeněk DANĚK; Lydie IZAKOVIČOVÁ HOLLÁ; Ondrej URBAN; Vit NAVRATIL; Robert LISCHKE; Tomas HARUSTIAK; Tomáš GROLICH; Vladimír PROCHÁZKA; Ondřej SLABÝ and Petra BOŘILOVÁ LINHARTOVÁ. Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study. \textit{Disease Markers}. LONDON: HINDAWI LTD, 2022, vol.~2022, August, p.~1-13. ISSN~0278-0240. Available from: https://doi.org/10.1155/2022/8790748.

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