Lack of Association between Epidermal Growth Factor or Its
Receptor and Reflux Esophagitis, Barrett’s Esophagus, and
Esophageal Adenocarcinoma: A Case-Control Study

Přehled o publikaci

J 2022

Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study

DEISSOVÁ, Tereza; Michaela CVANOVÁ; Zdeněk KALA; Zuzana JIRASKOVA ZAKOSTELSKA; Jiří DOLINA et al.

Základní údaje

Originální název

Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study

Autoři

Vydání

Disease Markers, LONDON, HINDAWI LTD, 2022, 0278-0240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00126886

Organizace

Lékařská fakulta – Masarykova univerzita – Repozitář

Klíčová slova anglicky

Epidermal Growth Factor; Reflux Esophagitis; Barrett's Esophagus; Esophageal Adenocarcinoma

Návaznosti

EF17_043/0009632, projekt VaV. NU20-03-00126, projekt VaV. 857560, interní kód Repo. RECETOX RI, velká výzkumná infrastruktura.

Změněno: 14. 6. 2025 00:50, RNDr. Daniel Jakubík

Anotace

V originále

gt;A EGFR (rs2227983) polymorphisms using the TaqMan quantitative polymerase chain reaction (qPCR). In random subgroups, the EGF and EGFR mRNA expressions were analyzed by reverse transcription qPCR in esophageal tissue with and without endoscopically visible pathological changes; and the EGF plasma levels were determined by enzyme-linked immunosorbent assay. None of the genotyped SNPs nor EGF-EGFR genotype interactions were associated with RE, BE, or EAC development (). Moreover, mRNA expression of neither EGF nor EGFR differed between samples of the esophageal tissue with and without endoscopically visible pathology () nor between samples from patients with different diagnoses, i.e., RE, BE, or EAC (). Nevertheless, the lower EGF mRNA expression in carriers of combined genotypes AA +61 EGF (rs4444903) and GG +142285 EGFR (rs2227983; ) suggests a possible direct/indirect effect of EGF-EGFR gene interactions on EGF gene expression. In conclusion, EGF and EGFR gene variants and their mRNA/protein expression were not associated with RE, BE or EAC development in the Central European population.

Přiložené soubory

https://is.muni.cz/publication/2224704/2224704.pdf

Citovat

DEISSOVÁ, Tereza; Michaela CVANOVÁ; Zdeněk KALA; Zuzana JIRASKOVA ZAKOSTELSKA; Jiří DOLINA; Lumír KUNOVSKÝ; Radek KROUPA; Zdeněk PAVLOVSKÝ; Břetislav LIPOVÝ; Zdeněk DANĚK; Lydie IZAKOVIČOVÁ HOLLÁ; Ondrej URBAN; Vit NAVRATIL; Robert LISCHKE; Tomas HARUSTIAK; Tomáš GROLICH; Vladimír PROCHÁZKA; Ondřej SLABÝ a Petra BOŘILOVÁ LINHARTOVÁ. Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study. Disease Markers. LONDON: HINDAWI LTD, 2022, roč. 2022, August, s. 1-13. ISSN 0278-0240. Dostupné z: https://doi.org/10.1155/2022/8790748.

@article{75606,
   author = {Deissová, Tereza and Cvanová, Michaela and Kala, Zdeněk and Jiraskova Zakostelska, Zuzana and Dolina, Jiří and Kunovský, Lumír and Kroupa, Radek and Pavlovský, Zdeněk and Lipový, Břetislav and Daněk, Zdeněk and Izakovičová Hollá, Lydie and Urban, Ondrej and Navratil, Vit and Lischke, Robert and Harustiak, Tomas and Grolich, Tomáš and Procházka, Vladimír and Slabý, Ondřej and Bořilová Linhartová, Petra},
   article_location = {LONDON},
   article_number = {August},
   doi = {https://doi.org/10.1155/2022/8790748},
   keywords = {Epidermal Growth Factor; Reflux Esophagitis; Barrett's Esophagus; Esophageal Adenocarcinoma},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study},
   url = {https://www.hindawi.com/journals/dm/2022/8790748/},
   volume = {2022},
   year = {2022}
}

TY  - JOUR
ID  - 75606
AU  - Deissová, Tereza - Cvanová, Michaela - Kala, Zdeněk - Jiraskova Zakostelska, Zuzana - Dolina, Jiří - Kunovský, Lumír - Kroupa, Radek - Pavlovský, Zdeněk - Lipový, Břetislav - Daněk, Zdeněk - Izakovičová Hollá, Lydie - Urban, Ondrej - Navratil, Vit - Lischke, Robert - Harustiak, Tomas - Grolich, Tomáš - Procházka, Vladimír - Slabý, Ondřej - Bořilová Linhartová, Petra
PY  - 2022
TI  - Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study
JF  - Disease Markers
VL  - 2022
IS  - August
SP  - 1-13
EP  - 1-13
PB  - HINDAWI LTD
SN  - 0278-0240
KW  - Epidermal Growth Factor
KW  - Reflux Esophagitis
KW  - Barrett's Esophagus
KW  - Esophageal Adenocarcinoma
UR  - https://www.hindawi.com/journals/dm/2022/8790748/
N2  - gt;A EGFR (rs2227983) polymorphisms using the TaqMan quantitative polymerase chain reaction (qPCR). In random subgroups, the EGF and EGFR mRNA expressions were analyzed by reverse transcription qPCR in esophageal tissue with and without endoscopically visible pathological changes; and the EGF plasma levels were determined by enzyme-linked immunosorbent assay. None of the genotyped SNPs nor EGF-EGFR genotype interactions were associated with RE, BE, or EAC development (). Moreover, mRNA expression of neither EGF nor EGFR differed between samples of the esophageal tissue with and without endoscopically visible pathology () nor between samples from patients with different diagnoses, i.e., RE, BE, or EAC (). Nevertheless, the lower EGF mRNA expression in carriers of combined genotypes AA +61 EGF (rs4444903) and GG +142285 EGFR (rs2227983; ) suggests a possible direct/indirect effect of EGF-EGFR gene interactions on EGF gene expression. In conclusion, EGF and EGFR gene variants and their mRNA/protein expression were not associated with RE, BE or EAC development in the Central European population.
ER  -

DEISSOVÁ, Tereza; Michaela CVANOVÁ; Zdeněk KALA; Zuzana JIRASKOVA ZAKOSTELSKA; Jiří DOLINA; Lumír KUNOVSKÝ; Radek KROUPA; Zdeněk PAVLOVSKÝ; Břetislav LIPOVÝ; Zdeněk DANĚK; Lydie IZAKOVIČOVÁ HOLLÁ; Ondrej URBAN; Vit NAVRATIL; Robert LISCHKE; Tomas HARUSTIAK; Tomáš GROLICH; Vladimír PROCHÁZKA; Ondřej SLABÝ a Petra BOŘILOVÁ LINHARTOVÁ. Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study. \textit{Disease Markers}. LONDON: HINDAWI LTD, 2022, roč.~2022, August, s.~1-13. ISSN~0278-0240. Dostupné z: https://doi.org/10.1155/2022/8790748.

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