Unraveling CLL Pathogenic Cellular Mechanisms Through
Integrated Micro-C, Long-Read, and RNA-Seq data analysis

Přehled o publikaci

a 2024

Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis

PORC, Jakub Paweł; Karolína ČERNOVSKÁ; Kristýna TAUŠOVÁ; Kamila STRÁNSKÁ; Sabina ADAMOVÁ et al.

Basic information

Original name

Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis

Authors

Edition

13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon, 2024

Other information

Language

English

Type of outcome

Konferenční abstrakta

Country of publisher

Portugal

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Marked to be transferred to RIV

Yes

RIV identification code

RIV/00216224:14740/24:00138142

Organization

Středoevropský technologický institut – Repository – Repository

Keywords in English

CLL; NGS; structure variants; expression profile

Links

MUNI/A/1558/2023, interní kód Repo. NU21-08-00237, research and development project.

Changed: 23/12/2025 00:51, RNDr. Daniel Jakubík

Abstract

In the original language

Chronic lymphocytic leukemia (CLL) is characterized by a highly complex genetic landscape, leading to a variety of underlying mechanisms that contribute to disease progression. Those mechanisms are not fully understoood. The next-generation sequencing (NGS) methods provide limited insight into possible disease causes when interpreted indivudually. Integrating multiple genomic methods is necessary to gain a more comprehensive picture and account for complex interactions and pathway modifications. Our goal is to investigate the relationship between genomic aberrations, structure organization and chenges in expression profile in CLL. In particular, we aim to find structural variants and spatially associated regions that could possibly interfere with gene activity in a way that could result in their expression being changed.

Files attached

https://is.muni.cz/publication/2463473/Unraveling_CLL_Pathogenic_Cellular_Mechanisms.pdf

Cite

PORC, Jakub Paweł; Karolína ČERNOVSKÁ; Kristýna TAUŠOVÁ; Kamila STRÁNSKÁ; Sabina ADAMOVÁ; Jan SVATOŇ; Natálie KAZDOVÁ; Eva ONDROUŠKOVÁ; Marie JAROŠOVÁ; Michael DOUBEK; Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ. Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis. In 13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon. 2024.

@proceedings{68823,
   author = {Porc, Jakub Paweł and Černovská, Karolína and Taušová, Kristýna and Stránská, Kamila and Adamová, Sabina and Svatoň, Jan and Kazdová, Natálie and Ondroušková, Eva and Jarošová, Marie and Doubek, Michael and Pospíšilová, Šárka and Plevová, Karla},
   booktitle = {13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon},
   keywords = {CLL; NGS; structure variants; expression profile},
   language = {eng},
   title = {Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis},
   url = {https://eslho.org/news/13th-eslho-symposium/},
   year = {2024}
}

TY  - CONF
ID  - 68823
AU  - Porc, Jakub Paweł - Černovská, Karolína - Taušová, Kristýna - Stránská, Kamila - Adamová, Sabina - Svatoň, Jan - Kazdová, Natálie - Ondroušková, Eva - Jarošová, Marie - Doubek, Michael - Pospíšilová, Šárka - Plevová, Karla
PY  - 2024
TI  - Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis
KW  - CLL
KW  - NGS
KW  - structure variants
KW  - expression profile
UR  - https://eslho.org/news/13th-eslho-symposium/
N2  - Chronic lymphocytic leukemia (CLL) is characterized by a highly complex genetic landscape, leading to a variety of underlying mechanisms that contribute to disease progression. Those mechanisms are not fully understoood. The next-generation sequencing (NGS) methods provide limited insight into possible disease causes when interpreted indivudually. Integrating multiple genomic methods is necessary to gain a more comprehensive picture and account for complex interactions and pathway modifications. Our goal is to investigate the relationship between genomic aberrations, structure organization and chenges in expression profile in CLL. In particular, we aim to find structural variants and spatially associated regions that could possibly interfere with gene activity in a way that could result in their expression being changed.
ER  -

PORC, Jakub Paweł; Karolína ČERNOVSKÁ; Kristýna TAUŠOVÁ; Kamila STRÁNSKÁ; Sabina ADAMOVÁ; Jan SVATOŇ; Natálie KAZDOVÁ; Eva ONDROUŠKOVÁ; Marie JAROŠOVÁ; Michael DOUBEK; Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ. Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis. In \textit{13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon}. 2024.

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