Unraveling CLL Pathogenic Cellular Mechanisms Through
Integrated Micro-C, Long-Read, and RNA-Seq data analysis

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a 2024

Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis

PORC, Jakub Paweł; Karolína ČERNOVSKÁ; Kristýna TAUŠOVÁ; Kamila STRÁNSKÁ; Sabina ADAMOVÁ et al.

Základní údaje

Originální název

Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis

Autoři

Vydání

13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon, 2024

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakta

Stát vydavatele

Portugalsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/24:00138142

Organizace

Středoevropský technologický institut – Masarykova univerzita – Repozitář

Klíčová slova anglicky

CLL; NGS; structure variants; expression profile

Návaznosti

MUNI/A/1558/2023, interní kód Repo. NU21-08-00237, projekt VaV.

Změněno: 23. 12. 2025 00:51, RNDr. Daniel Jakubík

Anotace

V originále

Chronic lymphocytic leukemia (CLL) is characterized by a highly complex genetic landscape, leading to a variety of underlying mechanisms that contribute to disease progression. Those mechanisms are not fully understoood. The next-generation sequencing (NGS) methods provide limited insight into possible disease causes when interpreted indivudually. Integrating multiple genomic methods is necessary to gain a more comprehensive picture and account for complex interactions and pathway modifications. Our goal is to investigate the relationship between genomic aberrations, structure organization and chenges in expression profile in CLL. In particular, we aim to find structural variants and spatially associated regions that could possibly interfere with gene activity in a way that could result in their expression being changed.

Přiložené soubory

https://is.muni.cz/publication/2463473/Unraveling_CLL_Pathogenic_Cellular_Mechanisms.pdf

Citovat

PORC, Jakub Paweł; Karolína ČERNOVSKÁ; Kristýna TAUŠOVÁ; Kamila STRÁNSKÁ; Sabina ADAMOVÁ; Jan SVATOŇ; Natálie KAZDOVÁ; Eva ONDROUŠKOVÁ; Marie JAROŠOVÁ; Michael DOUBEK; Šárka POSPÍŠILOVÁ a Karla PLEVOVÁ. Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis. In 13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon. 2024.

@proceedings{68823,
   author = {Porc, Jakub Paweł and Černovská, Karolína and Taušová, Kristýna and Stránská, Kamila and Adamová, Sabina and Svatoň, Jan and Kazdová, Natálie and Ondroušková, Eva and Jarošová, Marie and Doubek, Michael and Pospíšilová, Šárka and Plevová, Karla},
   booktitle = {13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon},
   keywords = {CLL; NGS; structure variants; expression profile},
   language = {eng},
   title = {Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis},
   url = {https://eslho.org/news/13th-eslho-symposium/},
   year = {2024}
}

TY  - CONF
ID  - 68823
AU  - Porc, Jakub Paweł - Černovská, Karolína - Taušová, Kristýna - Stránská, Kamila - Adamová, Sabina - Svatoň, Jan - Kazdová, Natálie - Ondroušková, Eva - Jarošová, Marie - Doubek, Michael - Pospíšilová, Šárka - Plevová, Karla
PY  - 2024
TI  - Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis
KW  - CLL
KW  - NGS
KW  - structure variants
KW  - expression profile
UR  - https://eslho.org/news/13th-eslho-symposium/
N2  - Chronic lymphocytic leukemia (CLL) is characterized by a highly complex genetic landscape, leading to a variety of underlying mechanisms that contribute to disease progression. Those mechanisms are not fully understoood. The next-generation sequencing (NGS) methods provide limited insight into possible disease causes when interpreted indivudually. Integrating multiple genomic methods is necessary to gain a more comprehensive picture and account for complex interactions and pathway modifications. Our goal is to investigate the relationship between genomic aberrations, structure organization and chenges in expression profile in CLL. In particular, we aim to find structural variants and spatially associated regions that could possibly interfere with gene activity in a way that could result in their expression being changed.
ER  -

PORC, Jakub Paweł; Karolína ČERNOVSKÁ; Kristýna TAUŠOVÁ; Kamila STRÁNSKÁ; Sabina ADAMOVÁ; Jan SVATOŇ; Natálie KAZDOVÁ; Eva ONDROUŠKOVÁ; Marie JAROŠOVÁ; Michael DOUBEK; Šárka POSPÍŠILOVÁ a Karla PLEVOVÁ. Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis. In \textit{13th ESLHO Symposium: Multi-omics approaches for diagnosis and monitoring of hematological malignancies, Lisbon}. 2024.

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