Application of a pharmacokinetic model in characterizing
sources of polychlorinated biphenyl exposure and determining
threshold daily intakes for adverse health effects in infants
and toddlers

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Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl ...

Přehled o publikaci

J 2022

Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers

KOMPRDOVÁ, Klára; Elena DOMINGUEZ ROMERO; Brij Mohan SHARMA; Jiří KOMPRDA; Lisa Emily MELYMUK et al.

Základní údaje

Originální název

Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers

Autoři

Vydání

Science of the Total Environment, Amsterdam, Elsevier Science, 2022, 0048-9697

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00126067

Organizace

Přírodovědecká fakulta – Masarykova univerzita – Repozitář

Klíčová slova anglicky

Polychlorinated biphenyls; Human biomonieming; Physiologically based pharmacokinetic model; Daily intakes; Safety standards; Infant exposure

Návaznosti

EF15_003/0000469, projekt VaV. EF17_043/0009632, projekt VaV. RECETOX RI, velká výzkumná infrastruktura.

Změněno: 12. 6. 2025 00:49, RNDr. Daniel Jakubík

Anotace

V originále

amp; Safety (ANSES) and the German Environment Agency (UBA), above which possible adverse health effects may be expected. We estimated that up to 20.6% of Slovak children and up to 45.7% of Czech children at two years of age exceeded the threshold value of 700 ng.g(lipid)(-1 )in blood. Mean TEDIs leading to values of 500 ng.g(lipid)(-1) in blood for children up to two years ranged between 110 and 220 ng.kg(-1).bw.day(-1), varying according to breastfeeding duration. Breast milk and prenatal exposure contributed to 71 %-85% of PCBs exposure at two years of age. In contrast, the contributions of PCBs fmm dust and indoor air were negligible.

Přiložené soubory

https://is.muni.cz/publication/1861580/1861580.pdf

Citovat

KOMPRDOVÁ, Klára; Elena DOMINGUEZ ROMERO; Brij Mohan SHARMA; Jiří KOMPRDA; Lisa Emily MELYMUK; Ľubica MURÍNOVÁ PALKOVIČOVÁ; Kamil ČONKA; Tomáš TRNOVEC; Milena ČERNÁ; Beata DROBNÁ; Anna FABIŠIKOVÁ; Zuzana SEJÁKOVÁ STACHOVÁ a Martin SCHERINGER. Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers. Science of the Total Environment. Amsterdam: Elsevier Science, 2022, roč. 830, July 2022, s. 1-9. ISSN 0048-9697. Dostupné z: https://doi.org/10.1016/j.scitotenv.2022.154734.

@article{50868,
   author = {Komprdová, Klára and Dominguez Romero, Elena and Sharma, Brij Mohan and Komprda, Jiří and Melymuk, Lisa Emily and Murínová Palkovičová, Ľubica and Čonka, Kamil and Trnovec, Tomáš and Černá, Milena and Drobná, Beata and Fabišiková, Anna and Sejáková Stachová, Zuzana and Scheringer, Martin},
   article_location = {Amsterdam},
   article_number = {July 2022},
   doi = {https://doi.org/10.1016/j.scitotenv.2022.154734},
   keywords = {Polychlorinated biphenyls; Human biomonieming; Physiologically based pharmacokinetic model; Daily intakes; Safety standards; Infant exposure},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   title = {Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers},
   url = {https://www.sciencedirect.com/science/article/pii/S0048969722018277?via%3Dihub},
   volume = {830},
   year = {2022}
}

TY  - JOUR
ID  - 50868
AU  - Komprdová, Klára - Dominguez Romero, Elena - Sharma, Brij Mohan - Komprda, Jiří - Melymuk, Lisa Emily - Murínová Palkovičová, Ľubica - Čonka, Kamil - Trnovec, Tomáš - Černá, Milena - Drobná, Beata - Fabišiková, Anna - Sejáková Stachová, Zuzana - Scheringer, Martin
PY  - 2022
TI  - Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers
JF  - Science of the Total Environment
VL  - 830
IS  - July 2022
SP  - 1-9
EP  - 1-9
PB  - Elsevier Science
SN  - 0048-9697
KW  - Polychlorinated biphenyls
KW  - Human biomonieming
KW  - Physiologically based pharmacokinetic model
KW  - Daily intakes
KW  - Safety standards
KW  - Infant exposure
UR  - https://www.sciencedirect.com/science/article/pii/S0048969722018277?via%3Dihub
N2  - amp; Safety (ANSES) and the German Environment Agency (UBA), above which possible adverse health effects may be expected. We estimated that up to 20.6% of Slovak children and up to 45.7% of Czech children at two years of age exceeded the threshold value of 700 ng.g(lipid)(-1 )in blood. Mean TEDIs leading to values of 500 ng.g(lipid)(-1) in blood for children up to two years ranged between 110 and 220 ng.kg(-1).bw.day(-1), varying according to breastfeeding duration. Breast milk and prenatal exposure contributed to 71 %-85% of PCBs exposure at two years of age. In contrast, the contributions of PCBs fmm dust and indoor air were negligible.
ER  -

KOMPRDOVÁ, Klára; Elena DOMINGUEZ ROMERO; Brij Mohan SHARMA; Jiří KOMPRDA; Lisa Emily MELYMUK; Ľubica MURÍNOVÁ PALKOVIČOVÁ; Kamil ČONKA; Tomáš TRNOVEC; Milena ČERNÁ; Beata DROBNÁ; Anna FABIŠIKOVÁ; Zuzana SEJÁKOVÁ STACHOVÁ a Martin SCHERINGER. Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2022, roč.~830, July 2022, s.~1-9. ISSN~0048-9697. Dostupné z: https://doi.org/10.1016/j.scitotenv.2022.154734.

Přehled o publikaci

Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers

Základní údaje

Originální název

Autoři

Vydání

Další údaje

Jazyk

Typ výsledku

Stát vydavatele

Utajení

Odkazy

Označené pro přenos do RIV

Kód RIV

Organizace

DOI

UT WoS

EID Scopus

Klíčová slova anglicky

Návaznosti

Anotace

V originále

Přiložené soubory

Práva souboru pro čtení

Citovat