Přehled o publikaci
2022
Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers
KOMPRDOVÁ, Klára; Elena DOMINGUEZ ROMERO; Brij Mohan SHARMA; Jiří KOMPRDA; Lisa Emily MELYMUK et al.Basic information
Original name
Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers
Authors
KOMPRDOVÁ, Klára; Elena DOMINGUEZ ROMERO; Brij Mohan SHARMA; Jiří KOMPRDA; Lisa Emily MELYMUK; Ľubica MURÍNOVÁ PALKOVIČOVÁ; Kamil ČONKA; Tomáš TRNOVEC; Milena ČERNÁ; Beata DROBNÁ; Anna FABIŠIKOVÁ; Zuzana SEJÁKOVÁ STACHOVÁ and Martin SCHERINGER
Edition
Science of the Total Environment, Amsterdam, Elsevier Science, 2022, 0048-9697
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
Netherlands
Confidentiality degree
is not subject to a state or trade secret
References:
Marked to be transferred to RIV
Yes
RIV identification code
RIV/00216224:14310/22:00126067
Organization
Přírodovědecká fakulta – Repository – Repository
UT WoS
EID Scopus
Keywords in English
Polychlorinated biphenyls; Human biomonieming; Physiologically based pharmacokinetic model; Daily intakes; Safety standards; Infant exposure
Links
EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. RECETOX RI, large research infrastructures.
Changed: 12/6/2025 00:49, RNDr. Daniel Jakubík
Abstract
In the original language
amp; Safety (ANSES) and the German Environment Agency (UBA), above which possible adverse health effects may be expected. We estimated that up to 20.6% of Slovak children and up to 45.7% of Czech children at two years of age exceeded the threshold value of 700 ng.g(lipid)(-1 )in blood. Mean TEDIs leading to values of 500 ng.g(lipid)(-1) in blood for children up to two years ranged between 110 and 220 ng.kg(-1).bw.day(-1), varying according to breastfeeding duration. Breast milk and prenatal exposure contributed to 71 %-85% of PCBs exposure at two years of age. In contrast, the contributions of PCBs fmm dust and indoor air were negligible.
