Detailed Information on Publication Record
2019
Macro Histone Variants: Emerging Rheostats of Gastrointestinal Cancers
GIALLONGO, Sebastiano, Oriana LO RE and Manlio VINCIGUERRABasic information
Original name
Macro Histone Variants: Emerging Rheostats of Gastrointestinal Cancers
Authors
GIALLONGO, Sebastiano (380 Italy, belonging to the institution), Oriana LO RE (380 Italy, belonging to the institution) and Manlio VINCIGUERRA (380 Italy, guarantor)
Edition
Cancers, BASEL, MDPI, 2019, 2072-6694
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14110/19:00110284
Organization
Lékařská fakulta – Repository – Repository
UT WoS
000472738300089
Keywords in English
gastrointestinal cancer; histone variants; epigenetics; macroH2A
Změněno: 15/8/2020 05:32, RNDr. Daniel Jakubík
Abstract
V originále
Gastrointestinal cancers (GC) are malignancies involving the gastrointestinal (GI) tract and accessory organs of the digestive system, including the pancreas, liver, and gall bladder. GC is one of the most common cancers and contributes to more cancer-related deaths than cancers of any other system in the human body. Causative factors of GC have been consistently attributed to infections, smoking, an unhealthy diet, obesity, diabetes, and genetic factors. More recently, aberrant epigenetic regulation of gene expression has emerged as a new, fundamental pathway in GC pathogenesis. In this review, we summarize the role of the macroH2A histone family in GI cell function and malignant transformation, and highlight how this histone family may open up novel biomarkers for cancer detection, prediction, and response to treatment