Přehled o publikaci
2025
Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology
ZATLOUKALOVÁ, Eva; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; Iveta ŠEVČÍKOVÁ; A. KALINA et. al.Basic information
Original name
Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology
Authors
ZATLOUKALOVÁ, Eva; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; Iveta ŠEVČÍKOVÁ; A. KALINA; P. MARUSIČ; Martin PAIL; Markéta HERMANOVÁ; J. ZÁMEČNÍK and Milan BRÁZDIL
Edition
36th International Epilepsy Congress, Lisbon, Portugal, 2025
Other information
Language
English
Type of outcome
Presentations at conferences
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
Organization
Lékařská fakulta – Repository – Repository
Keywords in English
mesial temporal lobe epilepsy (MTLE); neurodegeneration; alpha-synuclein; TDP-43; pathological protein aggregates
Links
LX22NPO5107, research and development project. NU22-04-00366, research and development project.
Changed: 2/12/2025 00:51, RNDr. Daniel Jakubík
Abstract
In the original language
The growing body of evidence concerning the presence of pathological aggregates of hyperphosphorylated tau protein and beta-amyloid in resection specimens from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) is well-documented. Recent studies have also suggested alterations in serum levels of alpha-synuclein in this population1,2. Another protein associated with neurodegeneration, TAR DNA-binding protein 43 (TDP-43), has not yet been extensively studied in epilepsy patients. Given this background, the present study aims to investigate the presence of alphasynuclein and TDP-43 pathological aggregates in tissue samples from patients with MTLE sourced from two comprehensive tertiary epilepsy centers
