Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE)
Absence of Alpha-Synuclein and TDP-43 Pathology

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Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 ...

Přehled o publikaci

k 2025

Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology

ZATLOUKALOVÁ, Eva; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; Iveta ŠEVČÍKOVÁ; A. KALINA et. al.

Základní údaje

Originální název

Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology

Autoři

ZATLOUKALOVÁ, Eva; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; Iveta ŠEVČÍKOVÁ; A. KALINA; P. MARUSIČ; Martin PAIL; Markéta HERMANOVÁ; J. ZÁMEČNÍK a Milan BRÁZDIL

Vydání

36th International Epilepsy Congress, Lisbon, Portugal, 2025

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizace

Lékařská fakulta – Masarykova univerzita – Repozitář

Klíčová slova anglicky

mesial temporal lobe epilepsy (MTLE); neurodegeneration; alpha-synuclein; TDP-43; pathological protein aggregates

Návaznosti

LX22NPO5107, projekt VaV. NU22-04-00366, projekt VaV.

Změněno: 2. 12. 2025 00:51, RNDr. Daniel Jakubík

Anotace

V originále

The growing body of evidence concerning the presence of pathological aggregates of hyperphosphorylated tau protein and beta-amyloid in resection specimens from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) is well-documented. Recent studies have also suggested alterations in serum levels of alpha-synuclein in this population1,2. Another protein associated with neurodegeneration, TAR DNA-binding protein 43 (TDP-43), has not yet been extensively studied in epilepsy patients. Given this background, the present study aims to investigate the presence of alphasynuclein and TDP-43 pathological aggregates in tissue samples from patients with MTLE sourced from two comprehensive tertiary epilepsy centers

Přiložené soubory

https://is.muni.cz/publication/2536912/Neurodegeneration_in_Mesial_Temporal_Lobe_Epilepsy__MTLE__Absence_of_Alpha-Synuclein_and_TDP-43_Pathology.pdf Verze souboru

Citovat

ZATLOUKALOVÁ, Eva; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; Iveta ŠEVČÍKOVÁ; A. KALINA; P. MARUSIČ; Martin PAIL; Markéta HERMANOVÁ; J. ZÁMEČNÍK a Milan BRÁZDIL. Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology. In 36th International Epilepsy Congress, Lisbon, Portugal. 2025.

@proceedings{91277,
   author = {Zatloukalová, Eva and Hendrych, Michal and Dvořáková, Sylva and Ševčíková, Iveta and Kalina, A. and Marusič, P. and Pail, Martin and Hermanová, Markéta and Zámečník, J. and Brázdil, Milan},
   booktitle = {36th International Epilepsy Congress, Lisbon, Portugal},
   keywords = {mesial temporal lobe epilepsy (MTLE); neurodegeneration; alpha-synuclein; TDP-43; pathological protein aggregates},
   language = {eng},
   title = {Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology},
   year = {2025}
}

TY  - CONF
ID  - 91277
AU  - Zatloukalová, Eva - Hendrych, Michal - Dvořáková, Sylva - Ševčíková, Iveta - Kalina, A. - Marusič, P. - Pail, Martin - Hermanová, Markéta - Zámečník, J. - Brázdil, Milan
PY  - 2025
TI  - Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology
KW  - mesial temporal lobe epilepsy (MTLE)
KW  - neurodegeneration
KW  - alpha-synuclein
KW  - TDP-43
KW  - pathological protein aggregates
N2  - The growing body of evidence concerning the presence of pathological aggregates of hyperphosphorylated tau protein and beta-amyloid in resection specimens from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) is well-documented. Recent studies have also suggested alterations in serum levels of alpha-synuclein in this population1,2. Another protein associated with neurodegeneration, TAR DNA-binding protein 43 (TDP-43), has not yet been extensively studied in epilepsy patients. Given this background, the present study aims to investigate the presence of alphasynuclein and TDP-43 pathological aggregates in tissue samples from patients with MTLE sourced from two comprehensive tertiary epilepsy centers
ER  -

ZATLOUKALOVÁ, Eva; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; Iveta ŠEVČÍKOVÁ; A. KALINA; P. MARUSIČ; Martin PAIL; Markéta HERMANOVÁ; J. ZÁMEČNÍK a Milan BRÁZDIL. Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology. In \textit{36th International Epilepsy Congress, Lisbon, Portugal}. 2025.