Fecal tryptophan metabolite profiling in newborns in relation
to microbiota and antibiotic treatment

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Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

Přehled o publikaci

J 2024

Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

AUST, Anne-Christine, Veronika VIDOVÁ, Kateřina COUFALÍKOVÁ, Soňa SMETANOVÁ, Kristýna KOŽELUHOVÁ et. al.

Základní údaje

Originální název

Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

Autoři

AUST, Anne-Christine (276 Německo, domácí), Veronika VIDOVÁ (203 Česká republika, domácí), Kateřina COUFALÍKOVÁ (203 Česká republika, domácí), Soňa SMETANOVÁ (203 Česká republika, domácí), Kristýna KOŽELUHOVÁ (203 Česká republika, domácí), Lenka KOSEČKOVÁ MICENKOVÁ (703 Slovensko, domácí), Petra VÍDEŇSKÁ (203 Česká republika, domácí), Stanislav SMATANA (703 Slovensko, domácí), Eva BUDINSKÁ (703 Slovensko, domácí), Ivo BOREK (203 Česká republika), Petr JANKŮ (203 Česká republika), Jana KLÁNOVÁ (203 Česká republika, domácí), Zdeněk SPÁČIL (203 Česká republika, domácí) a Vojtěch THON (203 Česká republika, garant, domácí)

Vydání

Applied Microbiology and Biotechnology, Německo, SPRINGER, 2024, 0175-7598

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14310/24:00138633

Organizace

Přírodovědecká fakulta – Masarykova univerzita – Repozitář

DOI

http://dx.doi.org/10.1007/s00253-024-13339-4

UT WoS

001347995300001

EID Scopus

2-s2.0-85208602381

Klíčová slova anglicky

Stool; Microbiome; Tryptophan catabolites; Kynurenine; Vaginal delivery; Caesarean delivery

Návaznosti

EF15_003/0000469, projekt VaV. 857560, interní kód Repo. NCMG II, velká výzkumná infrastruktura. RECETOX RI II, velká výzkumná infrastruktura.

Změněno: 29. 5. 2025 00:49, RNDr. Daniel Jakubík

Anotace

V originále

In the first days of life, the newborns' intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the initiation of the tryptophan catabolism pathway. Further antibiotics (ATB) treatment of mothers before or during delivery affects the microbial and tryptophan metabolite composition of stool of the caesarean- and vaginal-delivered newborns. The determination of microbiome and levels of tryptophan microbial metabolites in meconium and stool can characterize intestinal colonization of a newborn. From 134 samples from the Central European Longitudinal Studies of Parents and Children: The Next Generation (CELSPAC: TNG) cohort study, 16S rRNA gene sequencing was performed, and microbial tryptophan metabolites were quantified using ultra-high-performance liquid chromatography with triple-quadrupole mass spectrometry. Microbial diversity and concentrations of tryptophan metabolites were significantly higher in stool compared to meconium. Treatment of mothers with ATB before or during delivery affects metabolite composition and microbial diversity in stool of vaginal- and caesarean-delivered newborns. Correlation of microbial and metabolite composition shows significant positive correlations of indol-3-lactic acid, N-acetyl-tryptophan and indol-3-acetic acid with Bifidobacterium, Bacteroides and Peptoclostridium. The positive effect of vaginal delivery on newborns' microbiome development is degraded when mother is treated with ATB before or during delivery.

Přiložené soubory

https://is.muni.cz/publication/2471450/2471450.pdf

Citovat

AUST, Anne-Christine, Veronika VIDOVÁ, Kateřina COUFALÍKOVÁ, Soňa SMETANOVÁ, Kristýna KOŽELUHOVÁ, Lenka KOSEČKOVÁ MICENKOVÁ, Petra VÍDEŇSKÁ, Stanislav SMATANA, Eva BUDINSKÁ, Ivo BOREK, Petr JANKŮ, Jana KLÁNOVÁ, Zdeněk SPÁČIL a Vojtěch THON. Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment. Applied Microbiology and Biotechnology. Německo: SPRINGER, 2024, roč. 108, č. 1, s. 1-14. ISSN 0175-7598. Dostupné z: https://dx.doi.org/10.1007/s00253-024-13339-4.

@article{67069,
   author = {Aust, AnneandChristine and Vidová, Veronika and Coufalíková, Kateřina and Smetanová, Soňa and Koželuhová, Kristýna and Kosečková Micenková, Lenka and Vídeňská, Petra and Smatana, Stanislav and Budinská, Eva and Borek, Ivo and Janků, Petr and Klánová, Jana and Spáčil, Zdeněk and Thon, Vojtěch},
   article_location = {Německo},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s00253-024-13339-4},
   keywords = {Stool; Microbiome; Tryptophan catabolites; Kynurenine; Vaginal delivery; Caesarean delivery},
   language = {eng},
   issn = {0175-7598},
   journal = {Applied Microbiology and Biotechnology},
   title = {Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment},
   url = {https://link.springer.com/article/10.1007/s00253-024-13339-4},
   volume = {108},
   year = {2024}
}

TY  - JOUR
ID  - 67069
AU  - Aust, Anne-Christine - Vidová, Veronika - Coufalíková, Kateřina - Smetanová, Soňa - Koželuhová, Kristýna - Kosečková Micenková, Lenka - Vídeňská, Petra - Smatana, Stanislav - Budinská, Eva - Borek, Ivo - Janků, Petr - Klánová, Jana - Spáčil, Zdeněk - Thon, Vojtěch
PY  - 2024
TI  - Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment
JF  - Applied Microbiology and Biotechnology
VL  - 108
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - SPRINGER
SN  - 0175-7598
KW  - Stool
KW  - Microbiome
KW  - Tryptophan catabolites
KW  - Kynurenine
KW  - Vaginal delivery
KW  - Caesarean delivery
UR  - https://link.springer.com/article/10.1007/s00253-024-13339-4
N2  - In the first days of life, the newborns' intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the initiation of the tryptophan catabolism pathway. Further antibiotics (ATB) treatment of mothers before or during delivery affects the microbial and tryptophan metabolite composition of stool of the caesarean- and vaginal-delivered newborns. The determination of microbiome and levels of tryptophan microbial metabolites in meconium and stool can characterize intestinal colonization of a newborn. From 134 samples from the Central European Longitudinal Studies of Parents and Children: The Next Generation (CELSPAC: TNG) cohort study, 16S rRNA gene sequencing was performed, and microbial tryptophan metabolites were quantified using ultra-high-performance liquid chromatography with triple-quadrupole mass spectrometry. Microbial diversity and concentrations of tryptophan metabolites were significantly higher in stool compared to meconium. Treatment of mothers with ATB before or during delivery affects metabolite composition and microbial diversity in stool of vaginal- and caesarean-delivered newborns. Correlation of microbial and metabolite composition shows significant positive correlations of indol-3-lactic acid, N-acetyl-tryptophan and indol-3-acetic acid with Bifidobacterium, Bacteroides and Peptoclostridium. The positive effect of vaginal delivery on newborns' microbiome development is degraded when mother is treated with ATB before or during delivery.
ER  -

AUST, Anne-Christine, Veronika VIDOVÁ, Kateřina COUFALÍKOVÁ, Soňa SMETANOVÁ, Kristýna KOŽELUHOVÁ, Lenka KOSEČKOVÁ MICENKOVÁ, Petra VÍDEŇSKÁ, Stanislav SMATANA, Eva BUDINSKÁ, Ivo BOREK, Petr JANKŮ, Jana KLÁNOVÁ, Zdeněk SPÁČIL a Vojtěch THON. Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment. \textit{Applied Microbiology and Biotechnology}. Německo: SPRINGER, 2024, roč.~108, č.~1, s.~1-14. ISSN~0175-7598. Dostupné z: https://dx.doi.org/10.1007/s00253-024-13339-4.