Fecal tryptophan metabolite profiling in newborns in relation
to microbiota and antibiotic treatment

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Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

Přehled o publikaci

J 2024

Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

AUST, Anne-Christine, Veronika VIDOVÁ, Kateřina COUFALÍKOVÁ, Soňa SMETANOVÁ, Kristýna KOŽELUHOVÁ et. al.

Basic information

Original name

Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

Authors

AUST, Anne-Christine (276 Germany, belonging to the institution), Veronika VIDOVÁ (203 Czech Republic, belonging to the institution), Kateřina COUFALÍKOVÁ (203 Czech Republic, belonging to the institution), Soňa SMETANOVÁ (203 Czech Republic, belonging to the institution), Kristýna KOŽELUHOVÁ (203 Czech Republic, belonging to the institution), Lenka KOSEČKOVÁ MICENKOVÁ (703 Slovakia, belonging to the institution), Petra VÍDEŇSKÁ (203 Czech Republic, belonging to the institution), Stanislav SMATANA (703 Slovakia, belonging to the institution), Eva BUDINSKÁ (703 Slovakia, belonging to the institution), Ivo BOREK (203 Czech Republic), Petr JANKŮ (203 Czech Republic), Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution), Zdeněk SPÁČIL (203 Czech Republic, belonging to the institution) and Vojtěch THON (203 Czech Republic, guarantor, belonging to the institution)

Edition

Applied Microbiology and Biotechnology, Německo, SPRINGER, 2024, 0175-7598

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14310/24:00138633

Organization

Přírodovědecká fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1007/s00253-024-13339-4

UT WoS

001347995300001

EID Scopus

2-s2.0-85208602381

Keywords in English

Stool; Microbiome; Tryptophan catabolites; Kynurenine; Vaginal delivery; Caesarean delivery

Links

EF15_003/0000469, research and development project. 857560, interní kód Repo. NCMG II, large research infrastructures. RECETOX RI II, large research infrastructures.

Changed: 29/5/2025 00:49, RNDr. Daniel Jakubík

Abstract

V originále

In the first days of life, the newborns' intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the initiation of the tryptophan catabolism pathway. Further antibiotics (ATB) treatment of mothers before or during delivery affects the microbial and tryptophan metabolite composition of stool of the caesarean- and vaginal-delivered newborns. The determination of microbiome and levels of tryptophan microbial metabolites in meconium and stool can characterize intestinal colonization of a newborn. From 134 samples from the Central European Longitudinal Studies of Parents and Children: The Next Generation (CELSPAC: TNG) cohort study, 16S rRNA gene sequencing was performed, and microbial tryptophan metabolites were quantified using ultra-high-performance liquid chromatography with triple-quadrupole mass spectrometry. Microbial diversity and concentrations of tryptophan metabolites were significantly higher in stool compared to meconium. Treatment of mothers with ATB before or during delivery affects metabolite composition and microbial diversity in stool of vaginal- and caesarean-delivered newborns. Correlation of microbial and metabolite composition shows significant positive correlations of indol-3-lactic acid, N-acetyl-tryptophan and indol-3-acetic acid with Bifidobacterium, Bacteroides and Peptoclostridium. The positive effect of vaginal delivery on newborns' microbiome development is degraded when mother is treated with ATB before or during delivery.

Files attached

https://is.muni.cz/publication/2471450/2471450.pdf

Cite

AUST, Anne-Christine, Veronika VIDOVÁ, Kateřina COUFALÍKOVÁ, Soňa SMETANOVÁ, Kristýna KOŽELUHOVÁ, Lenka KOSEČKOVÁ MICENKOVÁ, Petra VÍDEŇSKÁ, Stanislav SMATANA, Eva BUDINSKÁ, Ivo BOREK, Petr JANKŮ, Jana KLÁNOVÁ, Zdeněk SPÁČIL and Vojtěch THON. Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment. Applied Microbiology and Biotechnology. Německo: SPRINGER, 2024, vol. 108, No 1, p. 1-14. ISSN 0175-7598. Available from: https://dx.doi.org/10.1007/s00253-024-13339-4.

@article{67069,
   author = {Aust, AnneandChristine and Vidová, Veronika and Coufalíková, Kateřina and Smetanová, Soňa and Koželuhová, Kristýna and Kosečková Micenková, Lenka and Vídeňská, Petra and Smatana, Stanislav and Budinská, Eva and Borek, Ivo and Janků, Petr and Klánová, Jana and Spáčil, Zdeněk and Thon, Vojtěch},
   article_location = {Německo},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s00253-024-13339-4},
   keywords = {Stool; Microbiome; Tryptophan catabolites; Kynurenine; Vaginal delivery; Caesarean delivery},
   language = {eng},
   issn = {0175-7598},
   journal = {Applied Microbiology and Biotechnology},
   title = {Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment},
   url = {https://link.springer.com/article/10.1007/s00253-024-13339-4},
   volume = {108},
   year = {2024}
}

TY  - JOUR
ID  - 67069
AU  - Aust, Anne-Christine - Vidová, Veronika - Coufalíková, Kateřina - Smetanová, Soňa - Koželuhová, Kristýna - Kosečková Micenková, Lenka - Vídeňská, Petra - Smatana, Stanislav - Budinská, Eva - Borek, Ivo - Janků, Petr - Klánová, Jana - Spáčil, Zdeněk - Thon, Vojtěch
PY  - 2024
TI  - Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment
JF  - Applied Microbiology and Biotechnology
VL  - 108
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - SPRINGER
SN  - 0175-7598
KW  - Stool
KW  - Microbiome
KW  - Tryptophan catabolites
KW  - Kynurenine
KW  - Vaginal delivery
KW  - Caesarean delivery
UR  - https://link.springer.com/article/10.1007/s00253-024-13339-4
N2  - In the first days of life, the newborns' intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the initiation of the tryptophan catabolism pathway. Further antibiotics (ATB) treatment of mothers before or during delivery affects the microbial and tryptophan metabolite composition of stool of the caesarean- and vaginal-delivered newborns. The determination of microbiome and levels of tryptophan microbial metabolites in meconium and stool can characterize intestinal colonization of a newborn. From 134 samples from the Central European Longitudinal Studies of Parents and Children: The Next Generation (CELSPAC: TNG) cohort study, 16S rRNA gene sequencing was performed, and microbial tryptophan metabolites were quantified using ultra-high-performance liquid chromatography with triple-quadrupole mass spectrometry. Microbial diversity and concentrations of tryptophan metabolites were significantly higher in stool compared to meconium. Treatment of mothers with ATB before or during delivery affects metabolite composition and microbial diversity in stool of vaginal- and caesarean-delivered newborns. Correlation of microbial and metabolite composition shows significant positive correlations of indol-3-lactic acid, N-acetyl-tryptophan and indol-3-acetic acid with Bifidobacterium, Bacteroides and Peptoclostridium. The positive effect of vaginal delivery on newborns' microbiome development is degraded when mother is treated with ATB before or during delivery.
ER  -

AUST, Anne-Christine, Veronika VIDOVÁ, Kateřina COUFALÍKOVÁ, Soňa SMETANOVÁ, Kristýna KOŽELUHOVÁ, Lenka KOSEČKOVÁ MICENKOVÁ, Petra VÍDEŇSKÁ, Stanislav SMATANA, Eva BUDINSKÁ, Ivo BOREK, Petr JANKŮ, Jana KLÁNOVÁ, Zdeněk SPÁČIL and Vojtěch THON. Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment. \textit{Applied Microbiology and Biotechnology}. Německo: SPRINGER, 2024, vol.~108, No~1, p.~1-14. ISSN~0175-7598. Available from: https://dx.doi.org/10.1007/s00253-024-13339-4.