D 2022

Variable Stabilisation in Boolean Monotonic Model Pools

PASTVA, Samuel

Basic information

Original name

Variable Stabilisation in Boolean Monotonic Model Pools

Authors

PASTVA, Samuel

Edition

Cham, Computational Methods in Systems Biology, p. 122-137, 16 pp. 2022

Publisher

Springer

Other information

Language

English

Type of outcome

Proceedings paper

Confidentiality degree

is not subject to a state or trade secret

Publication form

electronic version available online

References:

Marked to be transferred to RIV

No

Organization

Fakulta informatiky – Repository – Repository

ISBN

978-3-031-15033-3

ISSN

Keywords in English

boolean network; monotonic function; influence graph

Links

GA22-10845S, research and development project.
Changed: 2/4/2025 00:50, RNDr. Daniel Jakubík

Abstract

In the original language

One of the central issues in logical modeling is whether a certain property of the model emerges due to its topological structure (i.e. its influence graph), or due to its dynamical structure (i.e. its logical update functions). In this paper, we practically evaluate a previously proposed formal instrument for studying this question: monotonic model pools and their associated skeleton Boolean networks. Specifically, we propose a simplified over-approximation theorem for skeleton networks and study the emergence of variable stability in these systems. Additionally, we consider the notion of minimal stabilizing interventions and show how to compute such interventions symbolically. We survey the practicality of this methodology on 100+ real-world Boolean networks.

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