Přehled o publikaci
2022
Variable Stabilisation in Boolean Monotonic Model Pools
PASTVA, SamuelBasic information
Original name
Variable Stabilisation in Boolean Monotonic Model Pools
Authors
PASTVA, Samuel
Edition
Cham, Computational Methods in Systems Biology, p. 122-137, 16 pp. 2022
Publisher
Springer
Other information
Language
English
Type of outcome
Proceedings paper
Confidentiality degree
is not subject to a state or trade secret
Publication form
electronic version available online
References:
Marked to be transferred to RIV
No
Organization
Fakulta informatiky – Repository – Repository
ISBN
978-3-031-15033-3
ISSN
UT WoS
Keywords in English
boolean network; monotonic function; influence graph
Links
GA22-10845S, research and development project.
Changed: 2/4/2025 00:50, RNDr. Daniel Jakubík
Abstract
In the original language
One of the central issues in logical modeling is whether a certain property of the model emerges due to its topological structure (i.e. its influence graph), or due to its dynamical structure (i.e. its logical update functions). In this paper, we practically evaluate a previously proposed formal instrument for studying this question: monotonic model pools and their associated skeleton Boolean networks. Specifically, we propose a simplified over-approximation theorem for skeleton networks and study the emergence of variable stability in these systems. Additionally, we consider the notion of minimal stabilizing interventions and show how to compute such interventions symbolically. We survey the practicality of this methodology on 100+ real-world Boolean networks.