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@article{60986,
author = {Pinto Vidal, Felipe Augusto and Novák, Jiří and Jílková, Simona Rozárka and Rusina, Tatsiana and Vrana, Branislav and Melymuk, Lisa Emily and Hilscherová, Klára},
article_location = {Amsterdam},
article_number = {May 2024},
doi = {http://dx.doi.org/10.1016/j.jhazmat.2024.133778},
keywords = {Indoor dust; Bioaccessibility; Endocrine disrupting chemicals; Human risk assessment; In vitro},
language = {eng},
issn = {0304-3894},
journal = {Journal of Hazardous Materials},
title = {Endocrine disrupting potential of total and bioaccessible extracts of dust from seven different types of indoor environment},
url = {https://www.sciencedirect.com/science/article/pii/S0304389424003571?via%3Dihub},
volume = {469},
year = {2024}
}
TY - JOUR
ID - 60986
AU - Pinto Vidal, Felipe Augusto - Novák, Jiří - Jílková, Simona Rozárka - Rusina, Tatsiana - Vrana, Branislav - Melymuk, Lisa Emily - Hilscherová, Klára
PY - 2024
TI - Endocrine disrupting potential of total and bioaccessible extracts of dust from seven different types of indoor environment
JF - Journal of Hazardous Materials
VL - 469
IS - May 2024
SP - 1-12
EP - 1-12
PB - Elsevier Science BV.
SN - 0304-3894
KW - Indoor dust
KW - Bioaccessibility
KW - Endocrine disrupting chemicals
KW - Human risk assessment
KW - In vitro
UR - https://www.sciencedirect.com/science/article/pii/S0304389424003571?via%3Dihub
N2 - exposure potential mostly limited to a few pollutant groups and indoor types. This study provides a comprehensive toxicological profile of chemical mixtures associated with dust from various types of indoor environments, namely cars, houses, prefabricated apartments, kindergartens, offices, public spaces, and schools. Organic extracts of two different polarities and bioaccessible extracts mimicking the gastrointestinal conditions were prepared from two different particle size fractions of dust. These extracts were tested on a battery of human cell -based bioassays to assess endocrine disrupting potentials. Furthermore, 155 chemicals from different pollutant groups were measured and their relevance for the bioactivity was determined using concentration addition modelling. The exhaustive and bioaccessible extracts of dust from the different microenvironments interfered with aryl hydrocarbon receptor, estrogen, androgen, glucocorticoid, and thyroid hormone (TH) receptor signalling, and with TH transport. Noteably, bioaccessible extracts from offices and public spaces showed higher estrogenic effects than the organic solvent extracts. 114 of the 155 targeted chemicals were detectable, but the observed bioactivity could be only marginally explained by the detected chemicals. Diverse toxicity patterns across different microenvironments that people inhabit throughout their lifetime indicate potential health and developmental risks, especially for children. Limited data on the endocrine disrupting potency of relevant chemical classes, especially those deployed as replacements for legacy contaminants, requires further study.
ER -
PINTO VIDAL, Felipe Augusto, Jiří NOVÁK, Simona Rozárka JÍLKOVÁ, Tatsiana RUSINA, Branislav VRANA, Lisa Emily MELYMUK and Klára HILSCHEROVÁ. Endocrine disrupting potential of total and bioaccessible extracts of dust from seven different types of indoor environment. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2024, vol.~469, May 2024, p.~1-12. ISSN~0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2024.133778.
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