ČERNOVSKÁ, Karolína, Jakub Paweł PORC, Kristýna ZÁVACKÁ, Kamila STRÁNSKÁ, Sabina ADAMOVÁ, Eva ONDROUŠKOVÁ, Marie JAROŠOVÁ, Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ. Resolving chromatin organization in chronic lymphocytic leukemia. In EMBL Conference Cancer Genomics 2023, Heidelberg, Německo. 2023.
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Basic information
Original name Resolving chromatin organization in chronic lymphocytic leukemia.
Authors ČERNOVSKÁ, Karolína, Jakub Paweł PORC, Kristýna ZÁVACKÁ, Kamila STRÁNSKÁ, Sabina ADAMOVÁ, Eva ONDROUŠKOVÁ, Marie JAROŠOVÁ, Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ.
Edition EMBL Conference Cancer Genomics 2023, Heidelberg, Německo, 2023.
Other information
Original language English
Type of outcome Konferenční abstrakta
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization Středoevropský technologický institut – Repository – Repository
Keywords in English chromosomal rearrangements; chronic lymphocytic leukemia; topologically associated domains
Links LX22NPO5102, research and development project. MUNI/A/1224/2022, interní kód Repo. NU21-08-00237, research and development project.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 28/3/2024 04:03.
Abstract
The spatial chromatin organization has been recognized as essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults. We are particularly interested in the analysis of long-distance chromatin interactions and the formation of topologically associated domains (TADs), which might play a role in CLL pathogenesis.
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