Podrobný výpis o publikaci

@proceedings{60430,
   author = {Dostálová, Lenka and Ledererová, Aneta and Peschelová, Helena and Loja, Tomáš and Šmída, Michal},
   booktitle = {XX. International Workshop on CLL (iwCLL 2023), Boston, USA},
   keywords = {CD20 antigen; rituximab; therapy of B-cell malignancies; CRISPR/Cas9 knockout screening},
   language = {eng},
   title = {Identification of novel targets that upregulate CD20 expression in rituximab-resistant cells with the use of genomewide CRISPR screening.},
   url = {https://www.vjhemonc.com/event/iwcll-2023/},
   year = {2023}
}

TY  - CONF
ID  - 60430
AU  - Dostálová, Lenka - Ledererová, Aneta - Peschelová, Helena - Loja, Tomáš - Šmída, Michal
PY  - 2023
TI  - Identification of novel targets that upregulate CD20 expression in rituximab-resistant cells with the use of genomewide CRISPR screening.
KW  - CD20 antigen
KW  - rituximab
KW  - therapy of B-cell malignancies
KW  - CRISPR/Cas9 knockout screening
UR  - https://www.vjhemonc.com/event/iwcll-2023/
N2  - CD20 antigen has been used as a target of monoclonal antibodies (mAb) such as rituximab (RTX) in the therapy of B-cell malignancies for more than two decades. However, CLL B cells tend to express lower levels of CD20 on their surface or downregulate it following the mAb treatment, resulting in mAb resistance and subsequently therapy failure. Therefore, it is crucial to investigate the regulation of CD20 in order to restore sensitivity to anti-CD20 mAb and enhance its efficacy. The aim of this project was to perform genome-wide CRISPR/Cas9 knockout screening to identify genes whose disruption upregulates CD20 surface expression in the resistant cells with low CD20 levels.
ER  - 

DOSTÁLOVÁ, Lenka, Aneta LEDEREROVÁ, Helena PESCHELOVÁ, Tomáš LOJA a Michal ŠMÍDA. Identification of novel targets that upregulate CD20 expression in rituximab-resistant cells with the use of genomewide CRISPR screening. In \textit{XX. International Workshop on CLL (iwCLL 2023), Boston, USA}. 2023.