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@proceedings{60429,
author = {Volakhava, Anastasiya and Pavlová, Šárka and Závacká, Kristýna and Pál, Karol and Krzyžánková, Marcela and Synáčková, Hana and Pospíšilová, Šárka and Mamedov, Ilgar and Plevová, Karla},
booktitle = {EMBL Conference Cancer Genomics 2023, Heidelberg, Německo},
keywords = {Retroelements; Long Interspersed Nucleic Elements; chronic lymphocytic leukemia},
language = {eng},
title = {Hide and seek retroelement activity in hematological malignancies.},
url = {https://www.embl.org/about/info/course-and-conference-office/events/can23-01/},
year = {2023}
}
TY - CONF
ID - 60429
AU - Volakhava, Anastasiya - Pavlová, Šárka - Závacká, Kristýna - Pál, Karol - Krzyžánková, Marcela - Synáčková, Hana - Pospíšilová, Šárka - Mamedov, Ilgar - Plevová, Karla
PY - 2023
TI - Hide and seek retroelement activity in hematological malignancies.
KW - Retroelements
KW - Long Interspersed Nucleic Elements
KW - chronic lymphocytic leukemia
UR - https://www.embl.org/about/info/course-and-conference-office/events/can23-01/
N2 - Retroelements (REs), which function via a “copy-and-paste” mechanism, comprise nearly half of the human genome. The Long Interspersed Nucleic Elements, type 1 (LINE-1 or L1) are the only active autonomous REs. They are able to retrotranspose other RNAs including Alu and SVA REs, and occasionally protein-coding RNAs. Retroelements are silenced via multiple mechanisms, but genomic instability of cancer cells often leads to aberrant disruption of RE repression and enhances their transposition activity. The main goal of our research is to explore RE activity in chronic lymphocytic leukemia (CLL) and myelodysplastic syndrome (MDS) and to study the impact of therapy and TP53 inactivation on RE activity. To identify tumor-specific RE insertions, we adopted a highly sensitive amplicon NGS protocol for localizing insertions of REs from Alu-Ya5, Alu-Yb8, or L1-HS families into their target genomic regions. In total, 99 samples from 17 MDS and 21 CLL patients, and 60 samples from 4 leukemic cell lines were analyzed.
ER -
VOLAKHAVA, Anastasiya, Šárka PAVLOVÁ, Kristýna ZÁVACKÁ, Karol PÁL, Marcela KRZYŽÁNKOVÁ, Hana SYNÁČKOVÁ, Šárka POSPÍŠILOVÁ, Ilgar MAMEDOV a Karla PLEVOVÁ. Hide and seek retroelement activity in hematological malignancies. In \textit{EMBL Conference Cancer Genomics 2023, Heidelberg, Německo}. 2023.
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