a
2023
Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies.
PORC, Jakub Paweł, Tomáš REIGL, Veronika NAVRKALOVÁ, Jakub HYNŠT, Karol PÁL et. al.
Základní údaje
Originální název
Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies.
Autoři
PORC, Jakub Paweł, Tomáš REIGL, Veronika NAVRKALOVÁ, Jakub HYNŠT, Karol PÁL, Kamila STRÁNSKÁ, Jana KOTAŠKOVÁ a Šárka POSPÍŠILOVÁ
Vydání
EMBL Conference Cancer Genomics 2023, Heidelberg, Německo, 2023
Další údaje
Typ výsledku
Konferenční abstrakta
Utajení
není předmětem státního či obchodního tajemství
Organizace
Středoevropský technologický institut – Masarykova univerzita – Repozitář
Klíčová slova anglicky
Next-generation sequencing; targeted NGS panel LYNX; cancer genomics
Návaznosti
LM2018140, projekt VaV. LX22NPO5102, projekt VaV. NU21-08-00237, projekt VaV. NU22-08-00227, projekt VaV.
V originále
Next-generation sequencing (NGS) is rapidly advancing technology in cancer genomics. The single NGS experiment can replace several laboratory tests and provide requested information about the tumor samples. However, new requirements for bioinformatic tools and computational resources are emerging in diagnostics and research. Following the development of an integrative, targeted NGS panel LYNX, enabling the detection of genetic markers recurring in lymphoid malignancies (PMID: 34082072), we focused on designing a LYNX bioinformatics tool, featuring all necessary analytical steps as well as a user interface (UI) for easy data representation and interpretation. State-of-the art resources were used to achieve our goal, such as React.js, D3.js visualisation library, Integrated Genome Browser and GATK industry standard variant calling pipeline.
Zobrazeno: 19. 6. 2025 08:45