Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic
Leukemia: Where They Come from and How They Affect p53
Function.

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Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How ...

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a 2023

Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.

PEŠOVÁ, Michaela, Veronika MANČÍKOVÁ, Robert HELMA, Šárka PAVLOVÁ, Václav HEJRET et. al.

Základní údaje

Originální název

Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.

Autoři

PEŠOVÁ, Michaela, Veronika MANČÍKOVÁ, Robert HELMA, Šárka PAVLOVÁ, Václav HEJRET, Petr TAUŠ, Jakub HYNŠT, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Jitka MALČÍKOVÁ a Šárka POSPÍŠILOVÁ

Vydání

PhD and PostDoc RETREAT, Sněžné, Milovy, 2023

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakta

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizace

Středoevropský technologický institut – Masarykova univerzita – Repozitář

Klíčová slova anglicky

Protein p53; tumor suppression; chronic lymphocytic leukemia;

Návaznosti

LX22NPO5102, projekt VaV. MUNI/A/1224/2022, interní kód Repo.

Změněno: 25. 3. 2024 03:21, RNDr. Daniel Jakubík

Anotace

V originále

Protein p53 has a central role in tumor suppression. Under normal conditions, p53 levels are kept low, but in response to DNA damage, p53 becomes stabilized and initiates the transcription of its target genes. In chronic lymphocytic leukemia (CLL), aberrations in the TP53 gene are associated with the aggressive disease since the function of p53 protein is impaired. However, the p53 function might also be disrupted by other mechanisms, e.g. altered phosphorylation, even in the wild-type protein. Therefore, we aimed to investigate the impact of p53 phosphorylation on p53 function in CLL and uncover what underlies the existence of possible different phosphorylation patterns.

Přiložené soubory

https://is.muni.cz/publication/2357974/Abstract_book_Joint_PhDPostDocRETREAT_2023.pdf

Citovat

PEŠOVÁ, Michaela, Veronika MANČÍKOVÁ, Robert HELMA, Šárka PAVLOVÁ, Václav HEJRET, Petr TAUŠ, Jakub HYNŠT, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Jitka MALČÍKOVÁ a Šárka POSPÍŠILOVÁ. Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function. In PhD and PostDoc RETREAT, Sněžné, Milovy. 2023.

@proceedings{60356,
   author = {Pešová, Michaela and Mančíková, Veronika and Helma, Robert and Pavlová, Šárka and Hejret, Václav and Tauš, Petr and Hynšt, Jakub and Plevová, Karla and Kotašková, Jana and Malčíková, Jitka and Pospíšilová, Šárka},
   booktitle = {PhD and PostDoc RETREAT, Sněžné, Milovy},
   keywords = {Protein p53; tumor suppression; chronic lymphocytic leukemia;},
   language = {eng},
   title = {Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.},
   url = {https://www.ceitec.eu/ceitec-postdoc-phd-retreat/a4548},
   year = {2023}
}

TY  - CONF
ID  - 60356
AU  - Pešová, Michaela - Mančíková, Veronika - Helma, Robert - Pavlová, Šárka - Hejret, Václav - Tauš, Petr - Hynšt, Jakub - Plevová, Karla - Kotašková, Jana - Malčíková, Jitka - Pospíšilová, Šárka
PY  - 2023
TI  - Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.
KW  - Protein p53
KW  - tumor suppression
KW  - chronic lymphocytic leukemia;
UR  - https://www.ceitec.eu/ceitec-postdoc-phd-retreat/a4548
N2  - Protein p53 has a central role in tumor suppression. Under normal conditions, p53 levels are kept low, but in response to DNA damage, p53 becomes stabilized and initiates the transcription of its target genes. In chronic lymphocytic leukemia (CLL), aberrations in the TP53 gene are associated with the aggressive disease since the function of p53 protein is impaired. However, the p53 function might also be disrupted by other mechanisms, e.g. altered phosphorylation, even in the wild-type protein. Therefore, we aimed to investigate the impact of p53 phosphorylation on p53 function in CLL and uncover what underlies the existence of possible different phosphorylation patterns.
ER  -

PEŠOVÁ, Michaela, Veronika MANČÍKOVÁ, Robert HELMA, Šárka PAVLOVÁ, Václav HEJRET, Petr TAUŠ, Jakub HYNŠT, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Jitka MALČÍKOVÁ a Šárka POSPÍŠILOVÁ. Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function. In \textit{PhD and PostDoc RETREAT, Sněžné, Milovy}. 2023.