Přehled o publikaci
2023
Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.
PEŠOVÁ, Michaela, Veronika MANČÍKOVÁ, Robert HELMA, Šárka PAVLOVÁ, Václav HEJRET et. al.Basic information
Original name
Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.
Authors
PEŠOVÁ, Michaela, Veronika MANČÍKOVÁ, Robert HELMA, Šárka PAVLOVÁ, Václav HEJRET, Petr TAUŠ, Jakub HYNŠT, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Jitka MALČÍKOVÁ and Šárka POSPÍŠILOVÁ
Edition
PhD and PostDoc RETREAT, Sněžné, Milovy, 2023
Other information
Language
English
Type of outcome
Konferenční abstrakta
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
References:
Organization
Středoevropský technologický institut – Repository – Repository
Keywords in English
Protein p53; tumor suppression; chronic lymphocytic leukemia;
Links
LX22NPO5102, research and development project. MUNI/A/1224/2022, interní kód Repo.
Changed: 25/3/2024 03:21, RNDr. Daniel Jakubík
Abstract
V originále
Protein p53 has a central role in tumor suppression. Under normal conditions, p53 levels are kept low, but in response to DNA damage, p53 becomes stabilized and initiates the transcription of its target genes. In chronic lymphocytic leukemia (CLL), aberrations in the TP53 gene are associated with the aggressive disease since the function of p53 protein is impaired. However, the p53 function might also be disrupted by other mechanisms, e.g. altered phosphorylation, even in the wild-type protein. Therefore, we aimed to investigate the impact of p53 phosphorylation on p53 function in CLL and uncover what underlies the existence of possible different phosphorylation patterns.
