ČERNOVSKÁ, Karolína, Jakub Paweł PORC, Kristýna ZÁVACKÁ, Eva ONDROUŠKOVÁ, Marie JAROŠOVÁ, Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ. Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia. In XXVIIth Biochemistry congress. 2023. ISBN 978-80-8240-048-2.
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Original name Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.
Authors ČERNOVSKÁ, Karolína, Jakub Paweł PORC, Kristýna ZÁVACKÁ, Eva ONDROUŠKOVÁ, Marie JAROŠOVÁ, Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ.
Edition XXVIIth Biochemistry congress, 2023.
Other information
Original language English
Type of outcome Konferenční abstrakta
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization Středoevropský technologický institut – Repository – Repository
ISBN 978-80-8240-048-2
Keywords in English chronic lymphocytic leukemia; complex karyotype; chromatin structure disruption
Links LX22NPO5102, research and development project. MUNI/A/1224/2022, interní kód Repo. NU21-08-00237, research and development project.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 25/3/2024 03:21.
Abstract
The spatial chromatin organization in the nucleus has been recognized to be essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling, affecting tumor phenotype. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia of adults in the Western world. We are particularly interested in the complex karyotype (CK) that is known to be associated with poor clinical outcome. We assume that CK plays a key role in chromatin structure disruption, consequently affecting CLL behavior.
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