Přehled o publikaci
2023
Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.
ČERNOVSKÁ, Karolína, Jakub Paweł PORC, Kristýna ZÁVACKÁ, Eva ONDROUŠKOVÁ, Marie JAROŠOVÁ et. al.Basic information
Original name
Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.
Authors
ČERNOVSKÁ, Karolína, Jakub Paweł PORC, Kristýna ZÁVACKÁ, Eva ONDROUŠKOVÁ, Marie JAROŠOVÁ, Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ
Edition
XXVIIth Biochemistry congress, 2023
Other information
Language
English
Type of outcome
Konferenční abstrakta
Country of publisher
Slovakia
Confidentiality degree
is not subject to a state or trade secret
References:
Organization
Středoevropský technologický institut – Repository – Repository
ISBN
978-80-8240-048-2
Keywords in English
chronic lymphocytic leukemia; complex karyotype; chromatin structure disruption
Links
LX22NPO5102, research and development project. MUNI/A/1224/2022, interní kód Repo. NU21-08-00237, research and development project.
Changed: 25/3/2024 03:21, RNDr. Daniel Jakubík
Abstract
V originále
The spatial chromatin organization in the nucleus has been recognized to be essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling, affecting tumor phenotype. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia of adults in the Western world. We are particularly interested in the complex karyotype (CK) that is known to be associated with poor clinical outcome. We assume that CK plays a key role in chromatin structure disruption, consequently affecting CLL behavior.
