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@proceedings{60350,
author = {Černovská, Karolína and Porc, Jakub Paweł and Závacká, Kristýna and Ondroušková, Eva and Jarošová, Marie and Pospíšilová, Šárka and Plevová, Karla},
booktitle = {XXVIIth Biochemistry congress},
keywords = {chronic lymphocytic leukemia; complex karyotype; chromatin structure disruption},
language = {eng},
isbn = {978-80-8240-048-2},
title = {Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.},
url = {https://ssbmb2023.sk/content/19-programme},
year = {2023}
}
TY - CONF
ID - 60350
AU - Černovská, Karolína - Porc, Jakub Paweł - Závacká, Kristýna - Ondroušková, Eva - Jarošová, Marie - Pospíšilová, Šárka - Plevová, Karla
PY - 2023
TI - Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.
SN - 9788082400482
KW - chronic lymphocytic leukemia
KW - complex karyotype
KW - chromatin structure disruption
UR - https://ssbmb2023.sk/content/19-programme
N2 - The spatial chromatin organization in the nucleus has been recognized to be essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling, affecting tumor phenotype. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia of adults in the Western world. We are particularly interested in the complex karyotype (CK) that is known to be associated with poor clinical outcome. We assume that CK plays a key role in chromatin structure disruption, consequently affecting CLL behavior.
ER -
ČERNOVSKÁ, Karolína, Jakub Paweł PORC, Kristýna ZÁVACKÁ, Eva ONDROUŠKOVÁ, Marie JAROŠOVÁ, Šárka POSPÍŠILOVÁ a Karla PLEVOVÁ. Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia. In \textit{XXVIIth Biochemistry congress}. 2023. ISBN~978-80-8240-048-2.
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