Can variants, reinfection, symptoms and test types affect
COVID-19 diagnostic performance? A large-scale retrospective
study of AG-RDTs during circulation of Delta and Omicron
variants, Czechia, December 2021 to February 2022

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Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A ...

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J 2023

Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022

KLIEGR, Tomáš; Jiří JARKOVSKÝ; Helena JIŘINCOVÁ; Jaroslav KUCHAŘ; Tomáš KAREL et. al.

Basic information

Original name

Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022

Authors

KLIEGR, Tomáš (203 Czech Republic); Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution); Helena JIŘINCOVÁ (203 Czech Republic); Jaroslav KUCHAŘ (203 Czech Republic); Tomáš KAREL (203 Czech Republic); David CHUDÁN (203 Czech Republic); Stanislav VOJÍŘ (203 Czech Republic); Michal ZAVŘEL (203 Czech Republic); Ondřej ŠANCA (203 Czech Republic) and Ruth TACHEZY (203 Czech Republic)

Edition

Euro surveillance, STOCKHOLM, CONTROL, 2023, 1025-496X

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

Sweden

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14110/23:00133457

Organization

Lékařská fakulta – Repository – Repository

DOI

http://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2200938

UT WoS

001198382000001

EID Scopus

2-s2.0-85171808891

Keywords in English

SARS-CoV-2; delta; omicron; rapid antigen test; reinfection; vaccination

Links

LX22NPO5103, research and development project.

Changed: 17/7/2024 06:02, RNDr. Daniel Jakubík

Abstract

V originále

lt; 0.05). Sensitivity in vaccinated individuals was lower for Omicron (OR = 0.94; 95% confidence interval (CI): 0.87-1.03), particularly in reinfections (OR = 0.83; 95% CI: 0.75-0.92). Saliva AG-RDT sensitivity was below average for both Delta (74.4%) and Omicron (78.4%). Tests on the European Union Category A list had higher sensitivity than tests in Category B. The highest sensitivity for Omicron (88.5%) was recorded for patients with loss of smell or taste, however, these symptoms were almost 10-fold less common than for Delta. The sensitivity of AG-RDTs performed on initially asymptomatic individuals done 1, 2 or 3 days before a positive PCR test was consistently lower for Omicron compared with Delta.ConclusionSensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.

Files attached

https://is.muni.cz/publication/2370278/Can_variants__reinfection__symptoms_and_test_types_affect_COVID-19_diagnostic_performance.pdf

Cite

KLIEGR, Tomáš; Jiří JARKOVSKÝ; Helena JIŘINCOVÁ; Jaroslav KUCHAŘ; Tomáš KAREL; David CHUDÁN; Stanislav VOJÍŘ; Michal ZAVŘEL; Ondřej ŠANCA and Ruth TACHEZY. Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022. Euro surveillance. STOCKHOLM: CONTROL, 2023, vol. 28, No 38, p. 1-14. ISSN 1025-496X. Available from: https://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2200938.

@article{59588,
   author = {Kliegr, Tomáš and Jarkovský, Jiří and Jiřincová, Helena and Kuchař, Jaroslav and Karel, Tomáš and Chudán, David and Vojíř, Stanislav and Zavřel, Michal and Šanca, Ondřej and Tachezy, Ruth},
   article_location = {STOCKHOLM},
   article_number = {38},
   doi = {http://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2200938},
   keywords = {SARS-CoV-2; delta; omicron; rapid antigen test; reinfection; vaccination},
   language = {eng},
   issn = {1025-496X},
   journal = {Euro surveillance},
   title = {Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022},
   url = {https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.38.2200938},
   volume = {28},
   year = {2023}
}

TY  - JOUR
ID  - 59588
AU  - Kliegr, Tomáš - Jarkovský, Jiří - Jiřincová, Helena - Kuchař, Jaroslav - Karel, Tomáš - Chudán, David - Vojíř, Stanislav - Zavřel, Michal - Šanca, Ondřej - Tachezy, Ruth
PY  - 2023
TI  - Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
JF  - Euro surveillance
VL  - 28
IS  - 38
SP  - 1-14
EP  - 1-14
PB  - CONTROL
SN  - 1025-496X
KW  - SARS-CoV-2
KW  - delta
KW  - omicron
KW  - rapid antigen test
KW  - reinfection
KW  - vaccination
UR  - https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.38.2200938
N2  - lt; 0.05). Sensitivity in vaccinated individuals was lower for Omicron (OR = 0.94; 95% confidence interval (CI): 0.87-1.03), particularly in reinfections (OR = 0.83; 95% CI: 0.75-0.92). Saliva AG-RDT sensitivity was below average for both Delta (74.4%) and Omicron (78.4%). Tests on the European Union Category A list had higher sensitivity than tests in Category B. The highest sensitivity for Omicron (88.5%) was recorded for patients with loss of smell or taste, however, these symptoms were almost 10-fold less common than for Delta. The sensitivity of AG-RDTs performed on initially asymptomatic individuals done 1, 2 or 3 days before a positive PCR test was consistently lower for Omicron compared with Delta.ConclusionSensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.
ER  -

KLIEGR, Tomáš; Jiří JARKOVSKÝ; Helena JIŘINCOVÁ; Jaroslav KUCHAŘ; Tomáš KAREL; David CHUDÁN; Stanislav VOJÍŘ; Michal ZAVŘEL; Ondřej ŠANCA and Ruth TACHEZY. Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022. \textit{Euro surveillance}. STOCKHOLM: CONTROL, 2023, vol.~28, No~38, p.~1-14. ISSN~1025-496X. Available from: https://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2200938.