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@article{59349,
author = {Rosolen, Valentina and Giordani, Elisa and Mariuz, Marika and Parpinel, Maria and Mustieles, Vicente and Gilles, Liese and Govarts, Eva and Martin, Laura Rodriguez and Baken, Kirsten and Schoeters, Greet and Sepai, Ovnair and Sovcikova, Eva and Fabelova, Lucia and Kohoutek, Jiří and Jensen, Tina Kold and Covaci, Adrian and Roggeman, Maarten and Melymuk, Lisa Emily and Klánová, Jana and Castano, Argelia and Lopez, Marta Esteban and Barbone, Fabio},
article_location = {BASEL},
article_number = {11},
doi = {http://dx.doi.org/10.3390/toxics11110878},
keywords = {human biomonitoring; children; organophosphate flame retardants; neurodevelopment; WISC; HBM4EU Aligned Studies},
language = {eng},
issn = {2305-6304},
journal = {Toxics},
title = {Cognitive Performance and Exposure to Organophosphate Flame Retardants in Children: Evidence from a Cross-Sectional Analysis of Two European Mother-Child Cohorts},
url = {https://www.mdpi.com/2305-6304/11/11/878},
volume = {11},
year = {2023}
}
TY - JOUR
ID - 59349
AU - Rosolen, Valentina - Giordani, Elisa - Mariuz, Marika - Parpinel, Maria - Mustieles, Vicente - Gilles, Liese - Govarts, Eva - Martin, Laura Rodriguez - Baken, Kirsten - Schoeters, Greet - Sepai, Ovnair - Sovcikova, Eva - Fabelova, Lucia - Kohoutek, Jiří - Jensen, Tina Kold - Covaci, Adrian - Roggeman, Maarten - Melymuk, Lisa Emily - Klánová, Jana - Castano, Argelia - Lopez, Marta Esteban - Barbone, Fabio
PY - 2023
TI - Cognitive Performance and Exposure to Organophosphate Flame Retardants in Children: Evidence from a Cross-Sectional Analysis of Two European Mother-Child Cohorts
JF - Toxics
VL - 11
IS - 11
SP - 1-15
EP - 1-15
PB - MDPI
SN - 2305-6304
KW - human biomonitoring
KW - children
KW - organophosphate flame retardants
KW - neurodevelopment
KW - WISC
KW - HBM4EU Aligned Studies
UR - https://www.mdpi.com/2305-6304/11/11/878
N2 - The knowledge of the effects of organophosphate flame retardants on children's neurodevelopment is limited. The purpose of the present research is to evaluate the association between exposure to organophosphate flame retardants and children's neurodevelopment in two European cohorts involved in the Human Biomonitoring Initiative Aligned Studies. The participants were school-aged children belonging to the Odense Child Cohort (Denmark) and the PCB cohort (Slovakia). In each cohort, the children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score of the Wechsler Intelligence Scale for Children, using two different editions. The children's urine samples, collected at one point in time, were analyzed for several metabolites of organophosphate flame retardants. The association between neurodevelopment and each organophosphate flame retardant metabolite was explored by applying separate multiple linear regressions based on the approach of MM-estimation in each cohort. In the Danish cohort, the mean +/- standard deviation for the neurodevelopment score was 98 +/- 12; the geometric mean (95% confidence interval (95% CI)) of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) standardized by creatinine (crt) was 0.52 mu g/g crt (95% CI = 0.49; 0.60), while that of diphenyl phosphate (DPHP) standardized by crt was 1.44 mu g/g crt (95% CI = 1.31; 1.58). The neurodevelopment score showed a small, negative, statistically imprecise trend with BDCIPP standardized by crt (beta = -1.30; 95%CI = -2.72; 0.11; p-value = 0.07) and no clear association with DPHP standardized by crt (beta = -0.98; 95%CI = -2.96; 0.99; p-value = 0.33). The neurodevelopment score showed a negative trend with BDCIPP (beta = -1.42; 95% CI = -2.70; -0.06; p-value = 0.04) and no clear association with DPHP (beta = -1.09; 95% CI = -2.87; 0.68; p-value = 0.23). In the Slovakian cohort, the mean +/- standard deviation for the neurodevelopment score was 81 +/- 15; the geometric mean of BDCIPP standardized by crt was 0.18 mu g/g crt (95% CI = 0.16; 0.20), while that of DPHP standardized by crt was 2.24 mu g/g crt (95% CI = 2.00; 3.52). The association of the neurodevelopment score with BDCIPP standardized by crt was -0.49 (95%CI = -1.85; 0.87; p-value = 0.48), and with DPHP standardized by crt it was -0.35 (95%CI = -1.90; 1.20; p-value = 0.66). No clear associations were observed between the neurodevelopment score and BDCIPP/DPHP concentrations that were not standardized by crt. No clear associations were observed with bis(1-chloro-2-propyl) phosphate (BCIPP) in either cohort, due to the low detection frequency of this compound. In conclusion, this study provides only limited evidence of an inverse association between neurodevelopment and exposure to BDCIPP and DPHP. The timing of exposure and effect modification of other organophosphate flame retardant metabolites and other substances should be the subject of further investigations that address this scientific hypothesis.
ER -
ROSOLEN, Valentina, Elisa GIORDANI, Marika MARIUZ, Maria PARPINEL, Vicente MUSTIELES, Liese GILLES, Eva GOVARTS, Laura Rodriguez MARTIN, Kirsten BAKEN, Greet SCHOETERS, Ovnair SEPAI, Eva SOVCIKOVA, Lucia FABELOVA, Jiří KOHOUTEK, Tina Kold JENSEN, Adrian COVACI, Maarten ROGGEMAN, Lisa Emily MELYMUK, Jana KLÁNOVÁ, Argelia CASTANO, Marta Esteban LOPEZ a Fabio BARBONE. Cognitive Performance and Exposure to Organophosphate Flame Retardants in Children: Evidence from a Cross-Sectional Analysis of Two European Mother-Child Cohorts. \textit{Toxics}. BASEL: MDPI, 2023, roč.~11, č.~11, s.~1-15. ISSN~2305-6304. Dostupné z: https://dx.doi.org/10.3390/toxics11110878.
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