Přehled o publikaci
2023
Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers
HRUŠKA, Pavel, Jan KUČERA, Daniela KURUCZOVÁ, Marek BUZGA, Matej PEKAŘ et. al.Basic information
Original name
Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers
Authors
HRUŠKA, Pavel (203 Czech Republic, guarantor, belonging to the institution), Jan KUČERA (203 Czech Republic, belonging to the institution), Daniela KURUCZOVÁ (703 Slovakia, belonging to the institution), Marek BUZGA, Matej PEKAŘ (703 Slovakia, belonging to the institution), Pavol HOLECZY, David POTĚŠIL (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic, belonging to the institution)
Edition
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, UNITED STATES, AMER PHYSIOLOGICAL SOC, 2023, 0193-1849
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
References:
RIV identification code
RIV/00216224:14110/23:00132473
Organization
Lékařská fakulta – Repository – Repository
UT WoS
001104868800001
EID Scopus
2-s2.0-85175878726
Keywords in English
obesity; proteomics; subcutaneous adipose tissue; type 2 diabetes; visceral adipose tissue
Links
EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. EF18_046/0015974, research and development project. MUNI/A/1343/2022, interní kód Repo. 857560, interní kód Repo. CIISB III, large research infrastructures. RECETOX RI II, large research infrastructures.
Changed: 3/11/2024 00:50, RNDr. Daniel Jakubík
Abstract
V originále
amp; NOTEWORTHY This study provides insights into distinct proteomic profiles of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and serum in patients with severe obesity and their associations with clinical traits and body composition. It underscores SAT's crucial role in obesity development and related complications, such as insulin resistance (IR) and type 2 diabetes (T2D). Our findings emphasize the importance of understanding the SAT and VAT balance in energy homeostasis, proteostasis, and the potential role of SAT capacity in the development of metabolic disorders.
