Unraveling adipose tissue proteomic landscapes in severe
obesity: insights into metabolic complications and potential
biomarkers

CSLog in Log in (EduId)

Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic ...

Přehled o publikaci

J 2023

Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers

HRUŠKA, Pavel; Jan KUČERA; Daniela KURUCZOVÁ; Marek BUZGA; Matej PEKAŘ et. al.

Basic information

Original name

Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers

Authors

HRUŠKA, Pavel; Jan KUČERA; Daniela KURUCZOVÁ; Marek BUZGA; Matej PEKAŘ; Pavol HOLECZY; David POTĚŠIL; Zbyněk ZDRÁHAL and Julie DOBROVOLNÁ

Edition

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, UNITED STATES, AMER PHYSIOLOGICAL SOC, 2023, 0193-1849

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14110/23:00132473

Organization

Lékařská fakulta – Repository – Repository

DOI

https://doi.org/10.1152/ajpendo.00153.2023

UT WoS

001104868800001

EID Scopus

2-s2.0-85175878726

Keywords in English

obesity; proteomics; subcutaneous adipose tissue; type 2 diabetes; visceral adipose tissue

Links

EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. EF18_046/0015974, research and development project. MUNI/A/1343/2022, interní kód Repo. 857560, interní kód Repo. CIISB III, large research infrastructures. RECETOX RI II, large research infrastructures.

Changed: 3/11/2024 00:50, RNDr. Daniel Jakubík

Abstract

In the original language

amp; NOTEWORTHY This study provides insights into distinct proteomic profiles of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and serum in patients with severe obesity and their associations with clinical traits and body composition. It underscores SAT's crucial role in obesity development and related complications, such as insulin resistance (IR) and type 2 diabetes (T2D). Our findings emphasize the importance of understanding the SAT and VAT balance in energy homeostasis, proteostasis, and the potential role of SAT capacity in the development of metabolic disorders.

Files attached

https://is.muni.cz/publication/2348417/2348417.pdf

Cite

HRUŠKA, Pavel; Jan KUČERA; Daniela KURUCZOVÁ; Marek BUZGA; Matej PEKAŘ; Pavol HOLECZY; David POTĚŠIL; Zbyněk ZDRÁHAL and Julie DOBROVOLNÁ. Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. UNITED STATES: AMER PHYSIOLOGICAL SOC, 2023, vol. 325, No 5, p. "E562"-"E580", 19 pp. ISSN 0193-1849. Available from: https://doi.org/10.1152/ajpendo.00153.2023.

@article{58690,
   author = {Hruška, Pavel and Kučera, Jan and Kuruczová, Daniela and Buzga, Marek and Pekař, Matej and Holeczy, Pavol and Potěšil, David and Zdráhal, Zbyněk and Dobrovolná, Julie},
   article_location = {UNITED STATES},
   article_number = {5},
   doi = {https://doi.org/10.1152/ajpendo.00153.2023},
   keywords = {obesity; proteomics; subcutaneous adipose tissue; type 2 diabetes; visceral adipose tissue},
   language = {eng},
   issn = {0193-1849},
   journal = {AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM},
   title = {Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers},
   url = {https://journals.physiology.org/doi/full/10.1152/ajpendo.00153.2023},
   volume = {325},
   year = {2023}
}

TY  - JOUR
ID  - 58690
AU  - Hruška, Pavel - Kučera, Jan - Kuruczová, Daniela - Buzga, Marek - Pekař, Matej - Holeczy, Pavol - Potěšil, David - Zdráhal, Zbyněk - Dobrovolná, Julie
PY  - 2023
TI  - Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers
JF  - AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
VL  - 325
IS  - 5
SP  - "E562"-"E580"
EP  - "E562"-"E580"
PB  - AMER PHYSIOLOGICAL SOC
SN  - 0193-1849
KW  - obesity
KW  - proteomics
KW  - subcutaneous adipose tissue
KW  - type 2 diabetes
KW  - visceral adipose tissue
UR  - https://journals.physiology.org/doi/full/10.1152/ajpendo.00153.2023
N2  - amp; NOTEWORTHY This study provides insights into distinct proteomic profiles of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and serum in patients with severe obesity and their associations with clinical traits and body composition. It underscores SAT's crucial role in obesity development and related complications, such as insulin resistance (IR) and type 2 diabetes (T2D). Our findings emphasize the importance of understanding the SAT and VAT balance in energy homeostasis, proteostasis, and the potential role of SAT capacity in the development of metabolic disorders.
ER  -

HRUŠKA, Pavel; Jan KUČERA; Daniela KURUCZOVÁ; Marek BUZGA; Matej PEKAŘ; Pavol HOLECZY; David POTĚŠIL; Zbyněk ZDRÁHAL and Julie DOBROVOLNÁ. Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers. \textit{AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM}. UNITED STATES: AMER PHYSIOLOGICAL SOC, 2023, vol.~325, No~5, p.~''E562''-''E580'', 19 pp. ISSN~0193-1849. Available from: https://doi.org/10.1152/ajpendo.00153.2023.