MEDAPPA, Monica, Petra POSPÍŠILOVÁ, Maria M FERNANDES, Lucy N JOHN, Camila G BEIRAS, Linda GRILLOVÁ, Jan OPPELT, Arka BANERJEE, Marti VALL-MAYANS, Oriol MITJÀ and David ŠMAJS. Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients’ ulcers in Namatanai District of Papua New Guinea. 2023.
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Original name Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients’ ulcers in Namatanai District of Papua New Guinea
Authors MEDAPPA, Monica, Petra POSPÍŠILOVÁ, Maria M FERNANDES, Lucy N JOHN, Camila G BEIRAS, Linda GRILLOVÁ, Jan OPPELT, Arka BANERJEE, Marti VALL-MAYANS, Oriol MITJÀ and David ŠMAJS.
Edition 2023.
Other information
Original language English
Type of outcome Presentations at conferences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Organization Lékařská fakulta – Repository – Repository
Keywords in English Treponema pallidum ssp. pertenue; low genetic diversity; Papua New Guinea
Links LX22NPO5103, research and development project.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 16/11/2023 03:43.
Abstract
Yaws is an endemic disease caused by Treponema pallidum subsp. pertenue (TPE) that primarily affects children in rural regions of the tropics. • Clinical manifestations in the primary stage include chronic skin ulcers and other skin lesions, potentially affecting bones and cartilage in the later stages. • A newly developed multilocus sequence typing (MLST) scheme for TPE isolates was used to characterize the bacterium causing yaws in the Namatanai District, New Ireland province of Papua New Guinea during the Yaws 3 Trial. • This multi-locus sequence typing (MLST) scheme was applied to TPE-containing clinical isolates obtained during a mass drug administration study conducted in the Namatanai District of Papua New Guinea between June 2018 and December 2019 (John et al. 2022). • Out of the 1081 samples collected, 302 (28.5%) tested positive for TPE DNA, and 255 (84.4%) of these samples were fully typed.
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