Přehled o publikaci
2023
Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients’ ulcers in Namatanai District of Papua New Guinea
MEDAPPA, Monica, Petra POSPÍŠILOVÁ, Maria M FERNANDES, Lucy N JOHN, Camila G BEIRAS et. al.Basic information
Original name
Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients’ ulcers in Namatanai District of Papua New Guinea
Authors
MEDAPPA, Monica, Petra POSPÍŠILOVÁ, Maria M FERNANDES, Lucy N JOHN, Camila G BEIRAS, Linda GRILLOVÁ, Jan OPPELT, Arka BANERJEE, Marti VALL-MAYANS, Oriol MITJÀ and David ŠMAJS
Edition
2023
Other information
Language
English
Type of outcome
Presentations at conferences
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
Organization
Lékařská fakulta – Repository – Repository
Keywords in English
Treponema pallidum ssp. pertenue; low genetic diversity; Papua New Guinea
Links
LX22NPO5103, research and development project.
Changed: 16/11/2023 03:43, RNDr. Daniel Jakubík
Abstract
V originále
Yaws is an endemic disease caused by Treponema pallidum subsp. pertenue (TPE) that primarily affects children in rural regions of the tropics. • Clinical manifestations in the primary stage include chronic skin ulcers and other skin lesions, potentially affecting bones and cartilage in the later stages. • A newly developed multilocus sequence typing (MLST) scheme for TPE isolates was used to characterize the bacterium causing yaws in the Namatanai District, New Ireland province of Papua New Guinea during the Yaws 3 Trial. • This multi-locus sequence typing (MLST) scheme was applied to TPE-containing clinical isolates obtained during a mass drug administration study conducted in the Namatanai District of Papua New Guinea between June 2018 and December 2019 (John et al. 2022). • Out of the 1081 samples collected, 302 (28.5%) tested positive for TPE DNA, and 255 (84.4%) of these samples were fully typed.
