Přehled o publikaci

Escherichia coli is a common Gram-negative bacterium colonizing human and animal intestines. Some strains can harbour various virulence factors and thus belong to the major causative agents of human and animal infections. Extraintestinal pathogenic E. coli (ExPEC) cause infections ranging from common cystitis to life-threatening septicemia. ExPEC strains encode for various combinations of virulence factors, which increase their virulence and their ability to survive in extraintestinal environments. In camel husbandry, E. coli is responsible for diarrheal conditions, and may also cause camelid uterine infections, resulting in spontaneous abortions and increased neonatal mortality. Bacteriocins are peptides or proteins produced by various bacteria with antimicrobial activity. Bacteriocins have a narrow spectrum of activity as they kill only related bacteria to the bacteriocin producer. Owing to their antimicrobial activity, they are used in food preservation and they have also promising potential in human and veterinary medicine. Although, camel intestinal pathogenic E. coli is well studied, a little is known about ExPEC causing deadly sepses in camel calves. The aim of this study was to characterize set of extraintestinal pathogenic E. coli (ExPEC) from camels and compare their characteristics with commensal E. coli.