Přehled o publikaci
2023
Sulfonothioated meso-Methyl BODIPY Shows Enhanced Uncaging Efficiency and Releases H2Sn
WOHLRABOVA, Lucie; Jana OKOROČENKOVA; Eduardo PALAO UTIEL; Erika KUZMOVA; Karel CHALUPSKY et al.Basic information
Original name
Sulfonothioated meso-Methyl BODIPY Shows Enhanced Uncaging Efficiency and Releases H2Sn
Authors
WOHLRABOVA, Lucie; Jana OKOROČENKOVA; Eduardo PALAO UTIEL; Erika KUZMOVA; Karel CHALUPSKY; Petr KLÁN and Tomáš SLANINA
Edition
Organic Letters, WASHINGTON, American Chemical Society, 2023, 1523-7060
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
References:
Marked to be transferred to RIV
Yes
RIV identification code
RIV/00216224:14310/23:00132247
Organization
Přírodovědecká fakulta – Repository – Repository
UT WoS
EID Scopus
Keywords in English
HYDROGEN-SULFIDE; CYTOTOXICITY; MITOCHONDRIA; ENERGY
Links
EF17_043/0009632, research and development project. 857560, interní kód Repo. RECETOX RI, large research infrastructures.
Changed: 20/6/2025 00:50, RNDr. Daniel Jakubík
Abstract
In the original language
meso-Met h y l BODIPY photocages stand out for their absorption properties and easy chromophore derivatization. However, their low uncaging efficiencies often hinder applications requiring release of protected substrates in high amounts. In this study, we demonstrate that the sulfonothioated BODIPY group photocleaves a sulfonylthio group from the meso-met h y l position with a 10-fold higher quantum yield than the most efficient leaving groups studied to date. Photocleavage, observed in solution and in cells, is accompanied by the spatiotemporally controlled photo-release of H2Sn. For this reason, sulfonothioated BODIPY may be applied in cell signaling, redox homeostasis, and metabolic regulation studies.
