Přehled o publikaci
2023
Comprehensive genomic profiling and individual therapeutic planning in high-risk/refractory pediatric solid tumors: A single-center real-world study.
SLABÝ, Ondřej; Petra POKORNÁ; Hana PÁLOVÁ; Michal KÝR; Peter MÚDRY et. al.Basic information
Original name
Comprehensive genomic profiling and individual therapeutic planning in high-risk/refractory pediatric solid tumors: A single-center real-world study.
Authors
SLABÝ, Ondřej; Petra POKORNÁ; Hana PÁLOVÁ; Michal KÝR; Peter MÚDRY and Jaroslav ŠTĚRBA
Edition
2023 ASCO Annual Meeting I, 2023
Other information
Language
English
Type of outcome
Konferenční abstrakta
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
References:
Organization
Lékařská fakulta – Repository – Repository
ISSN
UT WoS
001053772002601
Keywords in English
high-risk/refractory pediatric solid tumors; genomic profiling; individual therapeutic planning
Links
LX22NPO5102, research and development project. NU20-03-00240, research and development project.
Changed: 15/11/2023 03:33, RNDr. Daniel Jakubík
Abstract
V originále
gt; 10 mut/Mb). Lymphomas and CNS tumors showed the highest rate of patients with therapeutically actionable findings (60% and 56%, respectively), followed by neuroblastomas (36%), sarcomas (25%), and other solid tumors (23%). All results and individual treatment plans were discussed and approved at multidisciplinary molecular tumor boards. Conclusions: Precision medicine in pediatric oncology has rapidly developed over the last decade and resulted in new therapeutic options based on molecular biomarkers and increased our understanding of the complexity of pediatric malignancies.