Different pieces of the same puzzle: a multifaceted perspective
on the complex biological basis of Parkinson's disease

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Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of ...

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J 2023

Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease

MUELLER-NEDEBOCK, Amica C, Marieke C J DEKKER, Matthew J FARRER, Nobutaka HATTORI, Shen-Yang LIM et. al.

Basic information

Original name

Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease

Authors

MUELLER-NEDEBOCK, Amica C, Marieke C J DEKKER, Matthew J FARRER, Nobutaka HATTORI, Shen-Yang LIM, George D MELLICK, Irena REKTOROVÁ (203 Czech Republic, belonging to the institution), Mohamed SALAMA, Artur F S SCHUH, A Jon STOESSL, Carolyn M SUE, Ai Huey TAN, Rene L VIDAL, Christine KLEIN and Soraya BARDIEN (guarantor)

Edition

NPJ PARKINSONS DISEASE, BERLIN, NATURE PORTFOLIO, 2023, 2373-8057

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

Germany

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14740/23:00132025

Organization

Středoevropský technologický institut – Repository – Repository

DOI

http://dx.doi.org/10.1038/s41531-023-00535-8

UT WoS

001033548100001

EID Scopus

2-s2.0-85165248498

Keywords in English

Parkinson’s disease

Links

LX22NPO5107, research and development project. NU20-04-00294, research and development project. CZECRIN IV, large research infrastructures.

Changed: 22/8/2024 00:50, RNDr. Daniel Jakubík

Abstract

V originále

The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being 'discovered' over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen "PD experts" from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen.

Files attached

https://is.muni.cz/publication/2329918/Different_pieces_of_the_same_puzzle_a_multifaceted_perspective_on_the_complex_biological_basis_of_Parkinson_s_disease.pdf

Cite

MUELLER-NEDEBOCK, Amica C, Marieke C J DEKKER, Matthew J FARRER, Nobutaka HATTORI, Shen-Yang LIM, George D MELLICK, Irena REKTOROVÁ, Mohamed SALAMA, Artur F S SCHUH, A Jon STOESSL, Carolyn M SUE, Ai Huey TAN, Rene L VIDAL, Christine KLEIN and Soraya BARDIEN. Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease. NPJ PARKINSONS DISEASE. BERLIN: NATURE PORTFOLIO, 2023, vol. 9, No 1, p. 1-11. ISSN 2373-8057. Available from: https://dx.doi.org/10.1038/s41531-023-00535-8.

@article{58070,
   author = {MuellerandNedebock, Amica C and Dekker, Marieke C J and Farrer, Matthew J and Hattori, Nobutaka and Lim, ShenandYang and Mellick, George D and Rektorová, Irena and Salama, Mohamed and Schuh, Artur F S and Stoessl, A Jon and Sue, Carolyn M and Tan, Ai Huey and Vidal, Rene L and Klein, Christine and Bardien, Soraya},
   article_location = {BERLIN},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41531-023-00535-8},
   keywords = {Parkinson’s disease},
   language = {eng},
   issn = {2373-8057},
   journal = {NPJ PARKINSONS DISEASE},
   title = {Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease},
   url = {https://www.nature.com/articles/s41531-023-00535-8},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 58070
AU  - Mueller-Nedebock, Amica C - Dekker, Marieke C J - Farrer, Matthew J - Hattori, Nobutaka - Lim, Shen-Yang - Mellick, George D - Rektorová, Irena - Salama, Mohamed - Schuh, Artur F S - Stoessl, A Jon - Sue, Carolyn M - Tan, Ai Huey - Vidal, Rene L - Klein, Christine - Bardien, Soraya
PY  - 2023
TI  - Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease
JF  - NPJ PARKINSONS DISEASE
VL  - 9
IS  - 1
SP  - 1-11
EP  - 1-11
PB  - NATURE PORTFOLIO
SN  - 2373-8057
KW  - Parkinson’s disease
UR  - https://www.nature.com/articles/s41531-023-00535-8
N2  - The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being 'discovered' over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen "PD experts" from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen.
ER  -

MUELLER-NEDEBOCK, Amica C, Marieke C J DEKKER, Matthew J FARRER, Nobutaka HATTORI, Shen-Yang LIM, George D MELLICK, Irena REKTOROVÁ, Mohamed SALAMA, Artur F S SCHUH, A Jon STOESSL, Carolyn M SUE, Ai Huey TAN, Rene L VIDAL, Christine KLEIN and Soraya BARDIEN. Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease. \textit{NPJ PARKINSONS DISEASE}. BERLIN: NATURE PORTFOLIO, 2023, vol.~9, No~1, p.~1-11. ISSN~2373-8057. Available from: https://dx.doi.org/10.1038/s41531-023-00535-8.