Twenty-five years of epilepsy surgery at a Central European
comprehensive epilepsy center-Trends in intervention delay and
outcomes

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J 2023

Twenty-five years of epilepsy surgery at a Central European comprehensive epilepsy center-Trends in intervention delay and outcomes

VŠIANSKÝ, Vít, Milan BRÁZDIL, Ivan REKTOR, Irena DOLEŽALOVÁ, Jitka KOČVAROVÁ et. al.

Basic information

Original name

Twenty-five years of epilepsy surgery at a Central European comprehensive epilepsy center-Trends in intervention delay and outcomes

Authors

Edition

Epilepsia Open, HOBOKEN, WILEY, 2023, 2470-9239

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Lékařská fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1002/epi4.12769

UT WoS

001004555400001

Keywords in English

drug-resistant epilepsy; drug-resistant epilepsy epidemiology; drug-resistant epilepsy surgery

Links

LX22NPO5107, research and development project.

Changed: 24/1/2024 03:13, RNDr. Daniel Jakubík

Abstract

V originále

lt; 0.001). For resections, better outcomes (ILAE scores 1a-2) have been achieved in extratemporal lesional (0%-21%-61%, P = 0.01, at least 2-year follow-up) patients. In temporal lesional patients, outcomes remained unchanged (at least 77% success rate). A longer duration of epilepsy predicted a less favorable outcome for resective procedures (P = 0.024) in patients with disease duration of less than 25 years. SignificanceThe spectrum of epilepsy surgery is shifting toward nonlesional and extratemporal cases. While success rates of extratemporal resections at our center are getting better, the average duration of epilepsy before surgical intervention is still very long and is not improving. This underscores the need for stronger collaboration between epileptologists and outpatient neurologists to ensure prompt and effective treatment for patients with drug-resistant epilepsy.

Files attached

https://is.muni.cz/publication/2291649/Twenty-five_years_of_epilepsy_surgery_at_a_Central_European_comprehensive_epilepsy_center-Trends_in_intervention_delay_and_outcomes.pdf

Cite

VŠIANSKÝ, Vít, Milan BRÁZDIL, Ivan REKTOR, Irena DOLEŽALOVÁ, Jitka KOČVAROVÁ, Ondřej STRÝČEK, Jan HEMZA, Jan CHRASTINA, Eva BRICHTOVÁ, Ondřej HORÁK, Patrícia MUŽLAYOVÁ, Markéta HERMANOVÁ, Michal HENDRYCH and Martin PAIL. Twenty-five years of epilepsy surgery at a Central European comprehensive epilepsy center-Trends in intervention delay and outcomes. Epilepsia Open. HOBOKEN: WILEY, 2023, vol. 8, No 3, p. 991-1001. ISSN 2470-9239. Available from: https://dx.doi.org/10.1002/epi4.12769.

@article{56766,
   author = {Všianský, Vít and Brázdil, Milan and Rektor, Ivan and Doležalová, Irena and Kočvarová, Jitka and Strýček, Ondřej and Hemza, Jan and Chrastina, Jan and Brichtová, Eva and Horák, Ondřej and Mužlayová, Patrícia and Hermanová, Markéta and Hendrych, Michal and Pail, Martin},
   article_location = {HOBOKEN},
   article_number = {3},
   doi = {http://dx.doi.org/10.1002/epi4.12769},
   keywords = {drug-resistant epilepsy; drug-resistant epilepsy epidemiology; drug-resistant epilepsy surgery},
   language = {eng},
   issn = {2470-9239},
   journal = {Epilepsia Open},
   title = {Twenty-five years of epilepsy surgery at a Central European comprehensive epilepsy center-Trends in intervention delay and outcomes},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/epi4.12769},
   volume = {8},
   year = {2023}
}

TY  - JOUR
ID  - 56766
AU  - Všianský, Vít - Brázdil, Milan - Rektor, Ivan - Doležalová, Irena - Kočvarová, Jitka - Strýček, Ondřej - Hemza, Jan - Chrastina, Jan - Brichtová, Eva - Horák, Ondřej - Mužlayová, Patrícia - Hermanová, Markéta - Hendrych, Michal - Pail, Martin
PY  - 2023
TI  - Twenty-five years of epilepsy surgery at a Central European comprehensive epilepsy center-Trends in intervention delay and outcomes
JF  - Epilepsia Open
VL  - 8
IS  - 3
SP  - 991-1001
EP  - 991-1001
PB  - WILEY
SN  - 2470-9239
KW  - drug-resistant epilepsy
KW  - drug-resistant epilepsy epidemiology
KW  - drug-resistant epilepsy surgery
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/epi4.12769
N2  - lt; 0.001). For resections, better outcomes (ILAE scores 1a-2) have been achieved in extratemporal lesional (0%-21%-61%, P = 0.01, at least 2-year follow-up) patients. In temporal lesional patients, outcomes remained unchanged (at least 77% success rate). A longer duration of epilepsy predicted a less favorable outcome for resective procedures (P = 0.024) in patients with disease duration of less than 25 years. SignificanceThe spectrum of epilepsy surgery is shifting toward nonlesional and extratemporal cases. While success rates of extratemporal resections at our center are getting better, the average duration of epilepsy before surgical intervention is still very long and is not improving. This underscores the need for stronger collaboration between epileptologists and outpatient neurologists to ensure prompt and effective treatment for patients with drug-resistant epilepsy.
ER  -

VŠIANSKÝ, Vít, Milan BRÁZDIL, Ivan REKTOR, Irena DOLEŽALOVÁ, Jitka KOČVAROVÁ, Ondřej STRÝČEK, Jan HEMZA, Jan CHRASTINA, Eva BRICHTOVÁ, Ondřej HORÁK, Patrícia MUŽLAYOVÁ, Markéta HERMANOVÁ, Michal HENDRYCH and Martin PAIL. Twenty-five years of epilepsy surgery at a Central European comprehensive epilepsy center-Trends in intervention delay and outcomes. \textit{Epilepsia Open}. HOBOKEN: WILEY, 2023, vol.~8, No~3, p.~991-1001. ISSN~2470-9239. Available from: https://dx.doi.org/10.1002/epi4.12769.