FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential
Predictor of Response to Immune Checkpoint Inhibitors in
Patients with Advanced Melanoma and Non-Small Cell Lung Cancer

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FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune ...

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J 2023

FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer

GRELL, Peter, Simona BOŘILOVÁ, Pavel FABIAN, Iveta SELINGEROVA, David NOVAK et. al.

Basic information

Original name

FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer

Authors

GRELL, Peter, Simona BOŘILOVÁ, Pavel FABIAN, Iveta SELINGEROVA, David NOVAK, Petr MULLER, Igor KISS and Rostislav VYZULA

Edition

Cancers, BASEL, MDPI, 2023, 2072-6694

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

Switzerland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Lékařská fakulta – Repository – Repository

DOI

http://dx.doi.org/10.3390/cancers15061901

UT WoS

000957603500001

Keywords in English

immune checkpoint inhibitors; anti-tumor immunity; predictive biomarker; malignant melanoma; NSCLC

Links

LX22NPO5102, research and development project. BBMRI.cz IV, large research infrastructures.

Changed: 13/1/2024 03:24, RNDr. Daniel Jakubík

Abstract

V originále

gt;= 1 (p = 0.005, HR 0.26). In the NSCLC group, only FoxP3 positivity was associated with shorter PFS and OS. We found that FoxP3 negativity was linked with a better response to ICI in both histological groups.

Files attached

https://is.muni.cz/publication/2281537/FoxP3_Expression_in_Tumor-Infiltrating_Lymphocytes_as_Potential_Predictor_of_Response_to_Immune_Checkpoint_Inhibitors_in_Patients_with_Advanced_Melanoma_and_Non-Small_Cell_Lung_Cancer.pdf

Cite

GRELL, Peter, Simona BOŘILOVÁ, Pavel FABIAN, Iveta SELINGEROVA, David NOVAK, Petr MULLER, Igor KISS and Rostislav VYZULA. FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer. Cancers. BASEL: MDPI, 2023, vol. 15, No 6, p. 1-16. ISSN 2072-6694. Available from: https://dx.doi.org/10.3390/cancers15061901.

@article{55867,
   author = {Grell, Peter and Bořilová, Simona and Fabian, Pavel and Selingerova, Iveta and Novak, David and Muller, Petr and Kiss, Igor and Vyzula, Rostislav},
   article_location = {BASEL},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/cancers15061901},
   keywords = {immune checkpoint inhibitors; anti-tumor immunity; predictive biomarker; malignant melanoma; NSCLC},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer},
   url = {https://www.mdpi.com/2072-6694/15/6/1901},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 55867
AU  - Grell, Peter - Bořilová, Simona - Fabian, Pavel - Selingerova, Iveta - Novak, David - Muller, Petr - Kiss, Igor - Vyzula, Rostislav
PY  - 2023
TI  - FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer
JF  - Cancers
VL  - 15
IS  - 6
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 2072-6694
KW  - immune checkpoint inhibitors
KW  - anti-tumor immunity
KW  - predictive biomarker
KW  - malignant melanoma
KW  - NSCLC
UR  - https://www.mdpi.com/2072-6694/15/6/1901
N2  - gt;= 1 (p = 0.005, HR 0.26). In the NSCLC group, only FoxP3 positivity was associated with shorter PFS and OS. We found that FoxP3 negativity was linked with a better response to ICI in both histological groups.
ER  -

GRELL, Peter, Simona BOŘILOVÁ, Pavel FABIAN, Iveta SELINGEROVA, David NOVAK, Petr MULLER, Igor KISS and Rostislav VYZULA. FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer. \textit{Cancers}. BASEL: MDPI, 2023, vol.~15, No~6, p.~1-16. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers15061901.