Přehled o publikaci
2023
Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer
JANÁČOVÁ, Lucia; Michaela ŠTENCKOVÁ; Petr LAPČÍK; Šárka HRACHOVINOVÁ; Pavla BOUCHALOVÁ et. al.Basic information
Original name
Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer
Authors
JANÁČOVÁ, Lucia (703 Slovakia, belonging to the institution); Michaela ŠTENCKOVÁ; Petr LAPČÍK (203 Czech Republic, belonging to the institution); Šárka HRACHOVINOVÁ (203 Czech Republic, belonging to the institution); Pavla BOUCHALOVÁ (203 Czech Republic, belonging to the institution); David POTĚŠIL (203 Czech Republic, belonging to the institution); Roman HRSTKA; Petr MÜLLER and Pavel BOUCHAL (203 Czech Republic, guarantor, belonging to the institution)
Edition
SCIENTIFIC REPORTS, England, NATURE PORTFOLIO, 2023, 2045-2322
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
Germany
Confidentiality degree
is not subject to a state or trade secret
References:
RIV identification code
RIV/00216224:14310/23:00130354
Organization
Přírodovědecká fakulta – Repository – Repository
UT WoS
000954571900062
EID Scopus
2-s2.0-85146784426
Keywords in English
Breast cancer; Cell invasion; Protein–protein interaction networks; Proteomics; RNA
Links
EF18_046/0015974, research and development project. LM2018132, research and development project. LX22NPO5102, research and development project. MUNI/A/1313/2022, interní kód Repo. NU22-08-00230, research and development project. CIISB II, large research infrastructures. Czech-BioImaging II, large research infrastructures. NCMG II, large research infrastructures.
Changed: 3/11/2024 00:50, RNDr. Daniel Jakubík
Abstract
V originále
lt; 0.05) levels. Importantly, proteins driving MET signaling were less abundant in COMT overexpressing cells, and pull-down confirmed interaction between COMT and Kunitz-type protease inhibitor 2 (SPINT2), a negative regulator of MET (log2FC = 5.10, q = 1.04−7). In conclusion, COMT may act as tumor suppressor in ER dependent BC not only by detoxification of catechol estrogens but also by suppressing cell invasion and interplay with MET pathway.
