PANTŮČEK, Roman, Ivana MAŠLAŇOVÁ, Tibor BOTKA, Lucie KUNTOVÁ, Adéla FINSTRLOVÁ and Jiří DOŠKAŘ. Alternative antibacterial therapy using bacteriophages: Phage host interactions and phage therapy safety. In NIVB Meeting 2022. 2022. ISSN 2336-7210.
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Basic information
Original name Alternative antibacterial therapy using bacteriophages: Phage host interactions and phage therapy safety
Authors PANTŮČEK, Roman, Ivana MAŠLAŇOVÁ, Tibor BOTKA, Lucie KUNTOVÁ, Adéla FINSTRLOVÁ and Jiří DOŠKAŘ.
Edition NIVB Meeting 2022, 2022.
Other information
Original language English
Type of outcome Konferenční abstrakta
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization Přírodovědecká fakulta – Repository – Repository
ISSN 2336-7210
Keywords in English non-traditional antibacterials; phage therapy; bacteriophage; bacteriolysis
Links LX22NPO5103, research and development project.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 14/3/2023 03:36.
Abstract
Bacterial viruses (bacteriophages) have significant impact on the evolution of bacteria and regulation of bacterial populations, including the microflora of the human body. Due to the global antibiotic crisis, interest in the use of bacterial viruses, phage-derived enzybiotics and chemical compopunds inspired by structures and functions of phage proteins to combat bacterial infections has increased worldwide. Historical clinical data on the effective use of bacteriophages in patients exists from Eastern Europe, but no evidence of it has been validated under recent European Regulatory standards. Discussions in professional societies such as ESCMID Study Group for Non-traditional Antibacterial Therapy –ESGNTA are currently underway on setting the rules for production and safety of the use of bacteriophage preparations. The regulatory authorities also communicate an increased interest in the therapeutic use of bacteriophages. In July 2021, the European Pharmacopoeia Commission launched work on new general chapter on phage therapy active substances and medicinal products for human and veterinary use, establishing harmonised quality standards for phage therapy products and providing a framework for their safe use in European countries.
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  • a concrete person Mgr. Lucie Vařechová, uco 106253
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  • a concrete person Mgr. Jolana Surýnková, uco 220973
  • a concrete person Mgr. Michal Maňas, uco 2481
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