BELVONCIKOVA, Paulina, Petra ŠPLÍCHALOVÁ, Petra VÍDEŇSKÁ and Roman GARDLIK. The Human Mycobiome: Colonization, Composition and the Role in Health and Disease. Journal of Fungi. St. Alban-Anlage: MDPI, 2022, vol. 8, No 10, p. 1-26. ISSN 2309-608X. Available from: https://dx.doi.org/10.3390/jof8101046.
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Original name The Human Mycobiome: Colonization, Composition and the Role in Health and Disease
Authors BELVONCIKOVA, Paulina, Petra ŠPLÍCHALOVÁ, Petra VÍDEŇSKÁ and Roman GARDLIK.
Edition Journal of Fungi, St. Alban-Anlage, MDPI, 2022, 2309-608X.
Other information
Original language English
Type of outcome Article in a journal
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization Přírodovědecká fakulta – Repository – Repository
Doi http://dx.doi.org/10.3390/jof8101046
UT WoS 000873020800001
Keywords in English fungi; gut mycobiome; oral mycobiome; skin mycobiome; genitourinary tract mycobiome; respiratory tract mycobiome; colonization; composition; dysbiosis
Links EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. LM2018121, research and development project. 857560, interní kód Repo.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 20/1/2023 03:55.
Abstract
The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth. The initial mycobiome is influenced by the gestational age of a newborn, birth weight, delivery method and feeding method. During a human's life, the composition of the mycobiome is further influenced by a large number of endogenous and exogenous factors. The most important factors are diet, body weight, age, sex and antibiotic and antifungal therapy. The human mycobiome inhabits the oral cavity, gastrointestinal tract, respiratory tract, urogenital tract and skin. Its composition can influence the gut-brain axis through immune and non-immune mediated crosstalk systems. It also interacts with other commensals of the ecosystem through synergistic and antagonistic relationships. Moreover, colonization of the gut by opportunistic fungal pathogens in immunocompromised individuals can lead to clinically relevant disease states. Thus, the mycobiome represents an essential part of the microbiome associated with a variety of physiological and pathological processes. This review summarizes the current knowledge on the composition of the mycobiome in specific sites of the human body and its role in health and disease.
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