J 2022

Personal care product use and lifestyle affect phthalate and DINCH metabolite levels in teenagers and young adults

STUCHLÍK FIŠEROVÁ, Petra, Lisa Emily MELYMUK, Klára KOMPRDOVÁ, Elena DOMINGUEZ ROMERO, Martin SCHERINGER et. al.

Basic information

Original name

Personal care product use and lifestyle affect phthalate and DINCH metabolite levels in teenagers and young adults

Authors

STUCHLÍK FIŠEROVÁ, Petra (203 Czech Republic, belonging to the institution), Lisa Emily MELYMUK (124 Canada, belonging to the institution), Klára KOMPRDOVÁ (203 Czech Republic, belonging to the institution), Elena DOMINGUEZ ROMERO (724 Spain, belonging to the institution), Martin SCHERINGER (756 Switzerland, belonging to the institution), Jiří KOHOUTEK (203 Czech Republic, belonging to the institution), Petra PŘIBYLOVÁ (203 Czech Republic, belonging to the institution), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Pavel PILER (203 Czech Republic, belonging to the institution), Holger M. KOCH, Martin ZVONAŘ (203 Czech Republic, belonging to the institution), Marta ESTEBAN-LOPEZ, Argelia CASTANO and Jana KLÁNOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Environmental Research, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, 0013-9351

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

RIV identification code

RIV/00216224:14310/22:00126430

Organization

Přírodovědecká fakulta – Repository – Repository

UT WoS

000833518100002

EID Scopus

2-s2.0-85132533130

Keywords in English

Urine; Phthalates; Human biomonitoring; Plasticizers; Human exposure

Links

EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. 733032, interní kód Repo. 857560, interní kód Repo. RECETOX RI, large research infrastructures.
Changed: 11/6/2025 00:50, RNDr. Daniel Jakubík

Abstract

V originále

gt;99% of study participants. The highest median concentrations were found for metabolites of low-molecular-weight (LMW) phthalates: mono-n-butyl phthalate (MnBP), monoisobutyl phthalate (MiBP) and MEP (60.7; 52.6 and 17.6 mu g/L in young adults). 1,2-cyclohexanedicarboxylic acid diisononyl ester (DINCH) metabolites were present in 68.2% of the samples with a median of 1.24 mu g/L for both cohorts. Concentrations of MnBP and MiBP were similar to other European populations, but 5-6 times higher than in populations in North America. We also observed large variability in phthalate exposures within the study population, with 2-3 orders of magnitude differences in urinary metabolites between high and low exposed individuals. The concentrations varied with season, gender, age, and lifestyle factors. A relationship was found between high levels of MEP and high overall use of personal care products (PCPs). Cluster analysis suggested that phthalate exposures depend on season and multiple lifestyle factors, like time spent indoors and use of PCPs, which combine to lead to the observed widespread presence of phthalate metabolites in both study populations. Participants who spent more time indoors, particularly noticeably during colder months, had higher levels of high-molecular weight phthalate metabolites, whereas participants with higher PCP use, particularly women, tended to have higher concentration of LMW phthalate metabolites.

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