Thermostable FGF2 Polypeptide, Use Thereof

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P 2021

Thermostable FGF2 Polypeptide, Use Thereof

DVOŘÁK, Petr; Pavel KREJČÍ; Lukáš BÁLEK; Lívia EISELLEOVÁ; Žaneta KONEČNÁ et. al.

Basic information

Original name

Thermostable FGF2 Polypeptide, Use Thereof

Authors

DVOŘÁK, Petr; Pavel KREJČÍ; Lukáš BÁLEK; Lívia EISELLEOVÁ; Žaneta KONEČNÁ; Pavel DVOŘÁK; David BEDNÁŘ; Jan BREZOVSKÝ; Eva ŠEBESTOVÁ; Radka CHALOUPKOVÁ; Veronika ŠTĚPÁNKOVÁ; Pavel VAŇÁČEK; Zbyněk PROKOP; Jiří DAMBORSKÝ and Michaela BOSÁKOVÁ

Edition

Number: SG11201804402W, Publisher: Intellectual Property Office of Singapore (IPOS), Place of publication: Singapur, Owner's name: Masarykova univerzita; Enantis s.r.o. 2021

Other information

Language

English

Type of outcome

Patent

Country of publisher

Singapore

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14310/21:00121632

Organization

Přírodovědecká fakulta – Repository – Repository

Keywords in English

Fibroblast Growth Factor 2; FGF2

Links

LO1214, research and development project.

Changed: 1/6/2022 02:28, RNDr. Daniel Jakubík

Abstract

In the original language

The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.

Files attached

https://is.muni.cz/publication/1770461/40469SG2-CERT.PDF File version

Cite

@misc{50586,
   author = {Dvořák, Petr and Krejčí, Pavel and Bálek, Lukáš and Eiselleová, Lívia and Konečná, Žaneta and Dvořák, Pavel and Bednář, David and Brezovský, Jan and Šebestová, Eva and Chaloupková, Radka and Štěpánková, Veronika and Vaňáček, Pavel and Prokop, Zbyněk and Damborský, Jiří and Bosáková, Michaela},
   keywords = {Fibroblast Growth Factor 2; FGF2},
   language = {eng},
   title = {Thermostable FGF2 Polypeptide, Use Thereof},
   url = {https://ip2sg.ipos.gov.sg/RPS/WP/CM/IPDetailsPTP.aspx?AppNbr=CcxXbwRr2MxjDY%2fjMWYMXDp%2bmch23TSPlTg6Y%2bD%2bf9SlLC%2bPBJrAxdk2B92KNfmZA8MZExJ62KPKn1EjUS2xVprvblh2lT%2bp4LNArEn%2be%2b%2fHT2wwS2dEIhhN0kg1L1M13bYOHCzsIULGQqWSpuAwuILRNRyq7M9mVQLq0Ph46%2fKEq},
   year = {2021}
}

TY  - PAT
ID  - 50586
AU  - Dvořák, Petr - Krejčí, Pavel - Bálek, Lukáš - Eiselleová, Lívia - Konečná, Žaneta - Dvořák, Pavel - Bednář, David - Brezovský, Jan - Šebestová, Eva - Chaloupková, Radka - Štěpánková, Veronika - Vaňáček, Pavel - Prokop, Zbyněk - Damborský, Jiří - Bosáková, Michaela
PY  - 2021
TI  - Thermostable FGF2 Polypeptide, Use Thereof
KW  - Fibroblast Growth Factor 2
KW  - FGF2
UR  - https://ip2sg.ipos.gov.sg/RPS/WP/CM/IPDetailsPTP.aspx?AppNbr=CcxXbwRr2MxjDY%2fjMWYMXDp%2bmch23TSPlTg6Y%2bD%2bf9SlLC%2bPBJrAxdk2B92KNfmZA8MZExJ62KPKn1EjUS2xVprvblh2lT%2bp4LNArEn%2be%2b%2fHT2wwS2dEIhhN0kg1L1M13bYOHCzsIULGQqWSpuAwuILRNRyq7M9mVQLq0Ph46%2fKEq
N2  - The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
ER  -