Detailed Information on Publication Record

@article{50206,
   author = {Quin, Jaclyn Elizabeth and Sedmík, Jiří and Vukić, Dragana and Khan, Anzer and Keegan, Liam and O'Connell, Mary Anne},
   article_location = {Cambridge (MA)},
   article_number = {9},
   doi = {http://dx.doi.org/10.1016/j.tibs.2021.02.002},
   keywords = {RNA editing; double-stranded RNA (dsRNA); pattern recognition receptors (PRRs); interferon; antiviral responses; autoinflammatory disease},
   language = {eng},
   issn = {0968-0004},
   journal = {Trends in Biochemical Sciences},
   title = {ADAR RNA Modifications, the Epitranscriptome and Innate Immunity},
   url = {https://www.sciencedirect.com/science/article/pii/S0968000421000311?via%3Dihub},
   volume = {46},
   year = {2021}
}

TY  - JOUR
ID  - 50206
AU  - Quin, Jaclyn Elizabeth - Sedmík, Jiří - Vukić, Dragana - Khan, Anzer - Keegan, Liam - O'Connell, Mary Anne
PY  - 2021
TI  - ADAR RNA Modifications, the Epitranscriptome and Innate Immunity
JF  - Trends in Biochemical Sciences
VL  - 46
IS  - 9
SP  - 758-771
EP  - 758-771
PB  - Cell Press
SN  - 0968-0004
KW  - RNA editing
KW  - double-stranded RNA (dsRNA)
KW  - pattern recognition receptors (PRRs)
KW  - interferon
KW  - antiviral responses
KW  - autoinflammatory disease
UR  - https://www.sciencedirect.com/science/article/pii/S0968000421000311?via%3Dihub
N2  - Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deamination, cause a viral infection mimic syndrome, a congenital encephalitis with aberrant interferon induction. These Aicardi-Goutieres syndrome 6 mutations affect adenosine deaminase acting on RNA 1 (ADAR1), which generates inosines in endogenous double-stranded (ds)RNA. The inosine base alters dsRNA structure to prevent aberrant activation of antiviral cytosolic helicase RIG-I-like receptors. We review how effects of inosines, ADARs, and other modi-fied bases have been shown to be important in innate immunity and cancer.
ER  - 

QUIN, Jaclyn Elizabeth, Jiří SEDMÍK, Dragana VUKI$\backslash$'C, Anzer KHAN, Liam KEEGAN and Mary Anne O'CONNELL. ADAR RNA Modifications, the Epitranscriptome and Innate Immunity. \textit{Trends in Biochemical Sciences}. Cambridge (MA): Cell Press, 2021, vol.~46, No~9, p.~758-771. ISSN~0968-0004. Available from: https://dx.doi.org/10.1016/j.tibs.2021.02.002.