| MAZUR, Andrii, Pavel GRINKEVICH, Radka CHALOUPKOVÁ, Petra HAVLICKOVA, Barbora KASCAKOVA, Michal KUTY, Jiří DAMBORSKÝ, Ivana KUTA SMATANOVA and Tatyana PRUDNIKOVA. Structural Analysis of the Ancestral Haloalkane Dehalogenase AncLinB-DmbA. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol. 22, No 21, p. 1-14. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms222111992. |
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@article{48993,
author = {Mazur, Andrii and Grinkevich, Pavel and Chaloupková, Radka and Havlickova, Petra and Kascakova, Barbora and Kuty, Michal and Damborský, Jiří and Kuta Smatanova, Ivana and Prudnikova, Tatyana},
article_location = {Basel},
article_number = {21},
doi = {http://dx.doi.org/10.3390/ijms222111992},
keywords = {haloalkane dehalogenase; ancestral sequence reconstruction; structural analysis; halogenated pollutants},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Structural Analysis of the Ancestral Haloalkane Dehalogenase AncLinB-DmbA},
url = {https://www.mdpi.com/1422-0067/22/21/11992},
volume = {22},
year = {2021}
}
TY - JOUR
ID - 48993
AU - Mazur, Andrii - Grinkevich, Pavel - Chaloupková, Radka - Havlickova, Petra - Kascakova, Barbora - Kuty, Michal - Damborský, Jiří - Kuta Smatanova, Ivana - Prudnikova, Tatyana
PY - 2021
TI - Structural Analysis of the Ancestral Haloalkane Dehalogenase AncLinB-DmbA
JF - International Journal of Molecular Sciences
VL - 22
IS - 21
SP - 1-14
EP - 1-14
PB - Multidisciplinary Digital Publishing Institute
SN - 1422-0067
KW - haloalkane dehalogenase
KW - ancestral sequence reconstruction
KW - structural analysis
KW - halogenated pollutants
UR - https://www.mdpi.com/1422-0067/22/21/11992
N2 - amp; ANGS; resolution. Structural comparison of AncLinB-DmbA with their closely related descendants LinB and DmbA revealed some differences in overall structure and tunnel architecture. Newly prepared AncLinB-DmbA has the highest active site cavity volume and the biggest entrance radius on the main tunnel in comparison to descendant enzymes. Ancestral sequence reconstruction is a powerful technique to study molecular evolution and design robust proteins for enzyme technologies.
ER -
MAZUR, Andrii, Pavel GRINKEVICH, Radka CHALOUPKOVÁ, Petra HAVLICKOVA, Barbora KASCAKOVA, Michal KUTY, Jiří DAMBORSKÝ, Ivana KUTA SMATANOVA and Tatyana PRUDNIKOVA. Structural Analysis of the Ancestral Haloalkane Dehalogenase AncLinB-DmbA. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol.~22, No~21, p.~1-14. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms222111992.
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