MARQUEZ SANCHEZ - CARNERERO, Esther Maria, Marina RUSSO, Andreas Wolfgang JAKOB, Lucie MUCHOVA, Libor VÍTEK and Petr KLÁN. Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives. CHEMISTRY-SWITZERLAND. BASEL: MDPI, 2021, vol. 3, No 1, p. 238-255. ISSN 2624-8549. Available from: https://dx.doi.org/10.3390/chemistry3010018.
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Original name Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives
Authors MARQUEZ SANCHEZ - CARNERERO, Esther Maria (724 Spain, belonging to the institution), Marina RUSSO (380 Italy, belonging to the institution), Andreas Wolfgang JAKOB (276 Germany, belonging to the institution), Lucie MUCHOVA (203 Czech Republic), Libor VÍTEK and Petr KLÁN (203 Czech Republic, guarantor, belonging to the institution).
Edition CHEMISTRY-SWITZERLAND, BASEL, MDPI, 2021, 2624-8549.
Other information
Original language English
Type of outcome Article in a journal
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14310/21:00119612
Organization Přírodovědecká fakulta – Repository – Repository
Doi http://dx.doi.org/10.3390/chemistry3010018
UT WoS 000708214700018
Keywords in English BODIPY; photochemistry; carbon monoxide; photorelease; carbon monoxide-releasing molecules
Links EF17_043/0009632, research and development project. GA18-12477S, research and development project. LM2018121, research and development project. 857560, interní kód Repo.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 10/1/2023 03:47.
Abstract
Carbon monoxide (CO) is an endogenously produced signaling molecule involved in the control of a vast array of physiological processes. One of the strategies to administer therapeutic amounts of CO is the precise spatial and temporal control over its release from photoactivatable CO-releasing molecules (photoCORMs). Here we present the synthesis and photophysical and photochemical properties of a small library of meso-carboxy BODIPY derivatives bearing different substituents at positions 2 and 6. We show that the nature of substituents has a major impact on both their photophysics and the efficiency of CO photorelease. CO was found to be efficiently released from pi -extended 2,6-arylethynyl BODIPY derivatives possessing absorption spectra shifted to a more biologically desirable wavelength range. Selected photoCORMs were subjected to in vitro experiments that did not reveal any serious toxic effects, suggesting their potential for further biological research.
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