Endocrine disrupting potential of replacement flame
retardants-Review of current knowledge for nuclear receptors
associated with reproductive outcomes

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Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for ...

Přehled o publikaci

J 2021

Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes

BAJARD ÉP.ESNER, Lola Murielle, Chander Kant NEGI, Vicente MUSTIELES, Lisa Emily MELYMUK, Stephane JOMINI et. al.

Základní údaje

Originální název

Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes

Autoři

BAJARD ÉP.ESNER, Lola Murielle (250 Francie, domácí), Chander Kant NEGI (356 Indie, domácí), Vicente MUSTIELES (724 Španělsko), Lisa Emily MELYMUK (124 Kanada, domácí), Stephane JOMINI (250 Francie), Johanna BARTHELEMY-BERNERON (250 Francie), Mariana F. FERNANDEZ (724 Španělsko) a Luděk BLÁHA (203 Česká republika, garant, domácí)

Vydání

Environment International, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2021, 0160-4120

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14310/21:00122094

Organizace

Přírodovědecká fakulta – Masarykova univerzita – Repozitář

DOI

http://dx.doi.org/10.1016/j.envint.2021.106550

UT WoS

000652671200002

EID Scopus

2-s2.0-85103932738

Klíčová slova anglicky

Endocrine disruption; Nuclear receptors; Steroid hormones; Flame retardants; Emerging contaminants; ToxCast

Návaznosti

EF17_043/0009632, projekt VaV. 733032, interní kód Repo. 857560, interní kód Repo. 859891, interní kód Repo. RECETOX RI, velká výzkumná infrastruktura.

Změněno: 6. 6. 2025 00:49, RNDr. Daniel Jakubík

Anotace

V originále

Background and aim: Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce a large spectrum of adverse effects by interfering with the hormonal system. Rapid identification of potential EDCs using in vitro screenings is therefore critical, particularly for chemicals of emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and research needs regarding endocrine disrupting (ED) properties of replacement FRs and (2) potential EDCs among these emerging chemicals. Methods: A systematic search was performed from open literature and ToxCast/Tox21 programs, and results from in vitro tests on the activities of 52 replacement FRs towards five hormone nuclear receptors (NRs) associated with reproductive outcomes (estrogen, androgen, glucocorticoid, progesterone, and aryl hydrocarbon receptors) were compiled and organized into tables. Findings were complemented with information from structure-based in silico model predictions and in vivo information when relevant. Results: For the majority of the 52 replacement FRs, experimental in vitro data on activities towards these five NRs were either incomplete (15 FRs) or not found (24 FRs). Within the replacement FRs for which effect data were found, some appeared as candidate EDCs, such as triphenyl phosphate (TPhP) and tris(1,3-dichloropropyl) phosphate (TDCIPP). The search also revealed shared ED profiles. For example, anti-androgenic activity was reported for 19 FRs and predicted for another 21 FRs. Discussion: This comprehensive review points to critical gaps in knowledge on ED potential for many replacement FRs, including chemicals to which the general population is likely exposed. Although this review does not cover all possible characteristics of ED, it allowed the identification of potential EDCs associated with reproductive outcomes, calling for deeper evaluation and possibly future regulation of these chemicals. By identifying shared ED profiles, this work also raises concerns for mixture effects since the population is co-exposed to several FRs and other chemicals.

Přiložené soubory

https://is.muni.cz/publication/1786147/1786147.pdf

Citovat

BAJARD ÉP.ESNER, Lola Murielle, Chander Kant NEGI, Vicente MUSTIELES, Lisa Emily MELYMUK, Stephane JOMINI, Johanna BARTHELEMY-BERNERON, Mariana F. FERNANDEZ a Luděk BLÁHA. Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes. Environment International. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, roč. 153, August 2021, s. 1-12. ISSN 0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2021.106550.

@article{48233,
   author = {Bajard ép.Esner, Lola Murielle and Negi, Chander Kant and Mustieles, Vicente and Melymuk, Lisa Emily and Jomini, Stephane and BarthelemyandBerneron, Johanna and Fernandez, Mariana F. and Bláha, Luděk},
   article_location = {OXFORD},
   article_number = {August 2021},
   doi = {http://dx.doi.org/10.1016/j.envint.2021.106550},
   keywords = {Endocrine disruption; Nuclear receptors; Steroid hormones; Flame retardants; Emerging contaminants; ToxCast},
   language = {eng},
   issn = {0160-4120},
   journal = {Environment International},
   title = {Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes},
   url = {https://www.sciencedirect.com/science/article/pii/S0160412021001756?via%3Dihub},
   volume = {153},
   year = {2021}
}

TY  - JOUR
ID  - 48233
AU  - Bajard ép.Esner, Lola Murielle - Negi, Chander Kant - Mustieles, Vicente - Melymuk, Lisa Emily - Jomini, Stephane - Barthelemy-Berneron, Johanna - Fernandez, Mariana F. - Bláha, Luděk
PY  - 2021
TI  - Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes
JF  - Environment International
VL  - 153
IS  - August 2021
SP  - 1-12
EP  - 1-12
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 0160-4120
KW  - Endocrine disruption
KW  - Nuclear receptors
KW  - Steroid hormones
KW  - Flame retardants
KW  - Emerging contaminants
KW  - ToxCast
UR  - https://www.sciencedirect.com/science/article/pii/S0160412021001756?via%3Dihub
N2  - Background and aim: Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce a large spectrum of adverse effects by interfering with the hormonal system. Rapid identification of potential EDCs using in vitro screenings is therefore critical, particularly for chemicals of emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and research needs regarding endocrine disrupting (ED) properties of replacement FRs and (2) potential EDCs among these emerging chemicals. Methods: A systematic search was performed from open literature and ToxCast/Tox21 programs, and results from in vitro tests on the activities of 52 replacement FRs towards five hormone nuclear receptors (NRs) associated with reproductive outcomes (estrogen, androgen, glucocorticoid, progesterone, and aryl hydrocarbon receptors) were compiled and organized into tables. Findings were complemented with information from structure-based in silico model predictions and in vivo information when relevant. Results: For the majority of the 52 replacement FRs, experimental in vitro data on activities towards these five NRs were either incomplete (15 FRs) or not found (24 FRs). Within the replacement FRs for which effect data were found, some appeared as candidate EDCs, such as triphenyl phosphate (TPhP) and tris(1,3-dichloropropyl) phosphate (TDCIPP). The search also revealed shared ED profiles. For example, anti-androgenic activity was reported for 19 FRs and predicted for another 21 FRs. Discussion: This comprehensive review points to critical gaps in knowledge on ED potential for many replacement FRs, including chemicals to which the general population is likely exposed. Although this review does not cover all possible characteristics of ED, it allowed the identification of potential EDCs associated with reproductive outcomes, calling for deeper evaluation and possibly future regulation of these chemicals. By identifying shared ED profiles, this work also raises concerns for mixture effects since the population is co-exposed to several FRs and other chemicals.
ER  -

BAJARD ÉP.ESNER, Lola Murielle, Chander Kant NEGI, Vicente MUSTIELES, Lisa Emily MELYMUK, Stephane JOMINI, Johanna BARTHELEMY-BERNERON, Mariana F. FERNANDEZ a Luděk BLÁHA. Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes. \textit{Environment International}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, roč.~153, August 2021, s.~1-12. ISSN~0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2021.106550.