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@article{48202,
   author = {Marečková, Klára and Pačínková, Anna and Klasnja, Anja and Shin, Jean and Andrýsková, Lenka and Staňo Kozubík, Kateřina and Pausová, Zdenka and Brázdil, Milan and Paus, Tomáš},
   article_location = {Oxford},
   article_number = {2020},
   doi = {http://dx.doi.org/10.1016/j.nicl.2020.102458},
   keywords = {DNA methylation age;Anxiety;Gray matter volume;Frontal lobe;Sex differences},
   language = {eng},
   issn = {2213-1582},
   journal = {NeuroImage},
   title = {Epigenetic clock as a correlate of anxiety},
   url = {https://www.sciencedirect.com/science/article/pii/S2213158220302953},
   volume = {28},
   year = {2020}
}

TY  - JOUR
ID  - 48202
AU  - Marečková, Klára - Pačínková, Anna - Klasnja, Anja - Shin, Jean - Andrýsková, Lenka - Staňo Kozubík, Kateřina - Pausová, Zdenka - Brázdil, Milan - Paus, Tomáš
PY  - 2020
TI  - Epigenetic clock as a correlate of anxiety
JF  - NeuroImage
VL  - 28
IS  - 2020
SP  - 102458
EP  - 102458
PB  - Elsevier Science Ltd
SN  - 2213-1582
KW  - DNA methylation age;Anxiety;Gray matter volume;Frontal lobe;Sex differences
UR  - https://www.sciencedirect.com/science/article/pii/S2213158220302953
N2  - DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder, as compared with controls. Since MDD is highly correlated with anxiety, we hypothesized that symptoms of anxiety, as well as lower volume of grey matter (GM) in depression-related cortical regions, will be associated with faster epigenetic clock in a community-based sample of young adults. Participants included 88 young adults (53% men; 23–24 years of age) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) who participated in its neuroimaging follow-up and provided saliva samples for epigenetic analysis. Epigenetic age was calculated according to Horvath (Horvath, 2013). Women had slower epigenetic clock than men (Cohen’s d = 0.48). In women (but not men), slower epigenetic clock was associated with less symptoms of anxiety. In the brain, women (but not men) with slower epigenetic clock had greater GM volume in the cerebral cortex (brain size-corrected; R2 = 0.07). Lobe-specific analyses showed that in women (but not men), slower epigenetic clock was associated with greater GM volume in frontal lobe (R2 = 0.16), and that GM volume in frontal lobe mediated the relationship between the speed of epigenetic clock and anxiety trait (ab = 0.15, SE = 0.15, 95% CI [0.007; 0.369]). These findings were not replicated, however, in a community-based sample of adolescents (n = 129; 49% men; 12–19 years of age), possibly due to the different method of tissue collection (blood vs. saliva) or additional sources of variability in the cohort of adolescents (puberty stages, socioeconomic status, prenatal exposure to maternal smoking during pregnancy).
ER  - 

MAREČKOVÁ, Klára, Anna PAČÍNKOVÁ, Anja KLASNJA, Jean SHIN, Lenka ANDRÝSKOVÁ, Kateřina STAŇO KOZUBÍK, Zdenka PAUSOVÁ, Milan BRÁZDIL a Tomáš PAUS. Epigenetic clock as a correlate of anxiety. \textit{NeuroImage}. Oxford: Elsevier Science Ltd, 2020, roč.~28, č.~2020, s.~102458-102465. ISSN~2213-1582. Dostupné z: https://dx.doi.org/10.1016/j.nicl.2020.102458.