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@article{48200,
author = {Mazurenko, Stanislav},
article_location = {Weinheim},
article_number = {22},
doi = {http://dx.doi.org/10.1002/cctc.202000933},
keywords = {Database; Machine learning; Protein design; Protein engineering; Protein modifications},
language = {eng},
issn = {1867-3880},
journal = {ChemCatChem},
title = {Predicting protein stability and solubility changes upon mutations: data perspective},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202000933},
volume = {12},
year = {2020}
}
TY - JOUR
ID - 48200
AU - Mazurenko, Stanislav
PY - 2020
TI - Predicting protein stability and solubility changes upon mutations: data perspective
JF - ChemCatChem
VL - 12
IS - 22
SP - 5590-5598
EP - 5590-5598
PB - Wiley-VCH GmbH
SN - 1867-3880
KW - Database
KW - Machine learning
KW - Protein design
KW - Protein engineering
KW - Protein modifications
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202000933
N2 - Understanding mutational effects on protein stability and solubility is of particular importance for creating industrially relevant biocatalysts, resolving mechanisms of many human diseases, and producing efficient biopharmaceuticals, to name a few. Forin silicopredictions, the complexity of the underlying processes and increasing computational capabilities favor the use of machine learning. However, this approach requires sufficient training data of reasonable quality for making precise predictions. This minireview aims to summarize and scrutinize available mutational datasets commonly used for training predictors. We analyze their structure and discuss the possible directions of improvement in terms of data size, quality, and availability. We also present perspectives on the development of mutational data for accelerating the design of efficient predictors, introducing two new manually curated databases FireProt(DB)and SoluProtMut(DB)for protein stability and solubility, respectively.
ER -
MAZURENKO, Stanislav. Predicting protein stability and solubility changes upon mutations: data perspective. \textit{ChemCatChem}. Weinheim: Wiley-VCH GmbH, 2020, vol.~12, No~22, p.~5590-5598. ISSN~1867-3880. Available from: https://dx.doi.org/10.1002/cctc.202000933.
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