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@article{44569,
author = {Štacková, Lenka and Russo, Marina and Muchova, Lucie and Orel, Vojtěch and Vitek, Libor and Štacko, Peter and Klán, Petr},
article_location = {Weinheim},
article_number = {58},
doi = {http://dx.doi.org/10.1002/chem.202003272},
keywords = {CO release; cyanine; near-infrared light; photoCORM; photorelease},
language = {eng},
issn = {0947-6539},
journal = {Chemistry - A European Journal},
title = {Cyanine-Flavonol Hybrids for Near-Infrared Light-Activated Delivery of Carbon Monoxide},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202003272},
volume = {26},
year = {2020}
}
TY - JOUR
ID - 44569
AU - Štacková, Lenka - Russo, Marina - Muchova, Lucie - Orel, Vojtěch - Vitek, Libor - Štacko, Peter - Klán, Petr
PY - 2020
TI - Cyanine-Flavonol Hybrids for Near-Infrared Light-Activated Delivery of Carbon Monoxide
JF - Chemistry - A European Journal
VL - 26
IS - 58
SP - 13184-13190
EP - 13184-13190
PB - Wiley
SN - 0947-6539
KW - CO release
KW - cyanine
KW - near-infrared light
KW - photoCORM
KW - photorelease
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202003272
N2 - Carbon monoxide (CO) is an endogenous signaling molecule that controls a number of physiological processes. To circumvent the inherent toxicity of CO, light-activated CO-releasing molecules (photoCORMs) have emerged as an alternative for its administration. However, their wider application requires photoactivation using biologically benign visible and near-infrared (NIR) light. In this work, a strategy to access such photoCORMs by fusing two CO-releasing flavonol moieties with a NIR-absorbing cyanine dye is presented. These hybrids liberate two molecules of CO in high chemical yields upon activation with NIR light up to 820 nm and exhibit excellent uncaging cross-sections, which surpass the state-of-the-art by two orders of magnitude. Furthermore, the biocompatibility and applicability of the system in vitro and in vivo are demonstrated, and a mechanism of CO release is proposed. It is hoped that this strategy will stimulate the discovery of new classes of photoCORMs and accelerate the translation of CO-based phototherapy into practice.
ER -
ŠTACKOVÁ, Lenka, Marina RUSSO, Lucie MUCHOVA, Vojtěch OREL, Libor VITEK, Peter ŠTACKO a Petr KLÁN. Cyanine-Flavonol Hybrids for Near-Infrared Light-Activated Delivery of Carbon Monoxide. \textit{Chemistry - A European Journal}. Weinheim: Wiley, 2020, roč.~26, č.~58, s.~13184-13190. ISSN~0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.202003272.
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