This chapter presents the concepts and analysis of system and functional requirements for the database management system for neuro-informatics data. The basic idea is to enable the creation and sharing of biomedical and related data, resulting in several projects in the field of neuro-informatics and HMI. The main objective is to bring tools and methods for data collection, description and organization and the ability to choose any subset for further processing, where the results can be included back to the collection. An important feature is the ability to function in a distributed environment.