The first principle of the Evolutionary ontology is the statement that culture contradicts the nature in its structural basis. If we really want to know how it is possible we should consider the fundamental principles which stand behind the both nature and culture. Biological reality is basically connected with the famous Darwinian principle – the natural selection. Further, we are supposing that the structural information which makes up cultural reality is at last based upon human cognitive architecture of self-consciousness. We conclude that the principle of the natural selection and the principle of symbolic reduction of our unconscious cognitive processes (which is the principle of cultural reality) is in clear mutual contrast. That is why the cultural reality and the natural reality are incompatible.