Baseline and early changes in eosinophil count and
neutrophil-to-eosinophil ratio predict outcomes in metastatic
renal cell carcinoma treated with nivolumab

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Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes ...

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J 2025

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

FIALA, Ondrej; Katarina REJLEKOVA; Tomas BUCHLER; Hana STUDENTOVA; Alexandr POPRACH et al.

Basic information

Original name

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

Authors

Edition

SCIENTIFIC REPORTS, England, NATURE PORTFOLIO, 2025, 2045-2322

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

Germany

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Marked to be transferred to RIV

Organization

Lékařská fakulta – Repository – Repository

Keywords in English

Renal cell carcinoma; Eosinophils; Neutrophil-to-eosinophil ratio; Immunotherapy; Nivolumab

Links

LX22NPO5102, research and development project.

Changed: 27/2/2026 00:51, RNDr. Daniel Jakubík

Abstract

In the original language

lt; 65 (p = 0.025). The results of the present study suggest that eosinophil-based blood parameters including AEC and NER and their early dynamics during the course of treatment with nivolumab are promising and readily available prognostic biomarkers in patients with mRCC.

Files attached

https://is.muni.cz/publication/2556918/Baseline_and_early_changes_in_eosinophil_count_and_neutrophil-to-eosinophil_ratio_predict_outcomes_in_metastatic_renal_cell_carcinoma_treated_with_nivolumab.pdf

Cite

FIALA, Ondrej; Katarina REJLEKOVA; Tomas BUCHLER; Hana STUDENTOVA; Alexandr POPRACH; Michal VOCKA; Petr HOSEK; Jindrich KOPECKY; Martin MATEJU; Anezka ZEMANKOVA; Martina SPISAROVA; Michaela TKADLECOVA; Peter PRIESTER; Jan KOURIL; Radka LOHYNSKA; Lucie GRMELOVA; Alexander SAVKA; Katarina STEFANIKOVA; Jana OBERTOVA; Dominika SIKOVA; Petr STRANSKY; Bohuslav MELICHAR and Patrik PALACKA. Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab. SCIENTIFIC REPORTS. England: NATURE PORTFOLIO, 2025, vol. 16, No 1, p. 1-12. ISSN 2045-2322. Available from: https://doi.org/10.1038/s41598-025-32593-8.

@article{101821,
   author = {Fiala, Ondrej and Rejlekova, Katarina and Buchler, Tomas and Studentova, Hana and Poprach, Alexandr and Vocka, Michal and Hosek, Petr and Kopecky, Jindrich and Mateju, Martin and Zemankova, Anezka and Spisarova, Martina and Tkadlecova, Michaela and Priester, Peter and Kouril, Jan and Lohynska, Radka and Grmelova, Lucie and Savka, Alexander and Stefanikova, Katarina and Obertova, Jana and Sikova, Dominika and Stransky, Petr and Melichar, Bohuslav and Palacka, Patrik},
   article_location = {England},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-025-32593-8},
   keywords = {Renal cell carcinoma; Eosinophils; Neutrophil-to-eosinophil ratio; Immunotherapy; Nivolumab},
   language = {eng},
   issn = {2045-2322},
   journal = {SCIENTIFIC REPORTS},
   title = {Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab},
   url = {https://www.nature.com/articles/s41598-025-32593-8},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 101821
AU  - Fiala, Ondrej - Rejlekova, Katarina - Buchler, Tomas - Studentova, Hana - Poprach, Alexandr - Vocka, Michal - Hosek, Petr - Kopecky, Jindrich - Mateju, Martin - Zemankova, Anezka - Spisarova, Martina - Tkadlecova, Michaela - Priester, Peter - Kouril, Jan - Lohynska, Radka - Grmelova, Lucie - Savka, Alexander - Stefanikova, Katarina - Obertova, Jana - Sikova, Dominika - Stransky, Petr - Melichar, Bohuslav - Palacka, Patrik
PY  - 2025
TI  - Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
JF  - SCIENTIFIC REPORTS
VL  - 16
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - NATURE PORTFOLIO
SN  - 2045-2322
KW  - Renal cell carcinoma
KW  - Eosinophils
KW  - Neutrophil-to-eosinophil ratio
KW  - Immunotherapy
KW  - Nivolumab
UR  - https://www.nature.com/articles/s41598-025-32593-8
N2  - lt; 65 (p = 0.025). The results of the present study suggest that eosinophil-based blood parameters including AEC and NER and their early dynamics during the course of treatment with nivolumab are promising and readily available prognostic biomarkers in patients with mRCC.
ER  -

FIALA, Ondrej; Katarina REJLEKOVA; Tomas BUCHLER; Hana STUDENTOVA; Alexandr POPRACH; Michal VOCKA; Petr HOSEK; Jindrich KOPECKY; Martin MATEJU; Anezka ZEMANKOVA; Martina SPISAROVA; Michaela TKADLECOVA; Peter PRIESTER; Jan KOURIL; Radka LOHYNSKA; Lucie GRMELOVA; Alexander SAVKA; Katarina STEFANIKOVA; Jana OBERTOVA; Dominika SIKOVA; Petr STRANSKY; Bohuslav MELICHAR and Patrik PALACKA. Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab. \textit{SCIENTIFIC REPORTS}. England: NATURE PORTFOLIO, 2025, vol.~16, No~1, p.~1-12. ISSN~2045-2322. Available from: https://doi.org/10.1038/s41598-025-32593-8.

Přehled o publikaci

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

Basic information

Original name

Authors

Edition

Other information

Language

Type of outcome

Country of publisher

Confidentiality degree

References:

Marked to be transferred to RIV

Organization

DOI

UT WoS

EID Scopus

Keywords in English

Links

Abstract

In the original language

Files attached

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Cite