Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
FIALA, Ondrej; Katarina REJLEKOVA; Tomas BUCHLER; Hana STUDENTOVA; Alexandr POPRACH et al.
Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
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FIALA, Ondrej; Katarina REJLEKOVA; Tomas BUCHLER; Hana STUDENTOVA; Alexandr POPRACH; Michal VOCKA; Petr HOSEK; Jindrich KOPECKY; Martin MATEJU; Anezka ZEMANKOVA; Martina SPISAROVA; Michaela TKADLECOVA; Peter PRIESTER; Jan KOURIL; Radka LOHYNSKA; Lucie GRMELOVA; Alexander SAVKA; Katarina STEFANIKOVA; Jana OBERTOVA; Dominika SIKOVA; Petr STRANSKY; Bohuslav MELICHAR a Patrik PALACKA
lt; 65 (p = 0.025). The results of the present study suggest that eosinophil-based blood parameters including AEC and NER and their early dynamics during the course of treatment with nivolumab are promising and readily available prognostic biomarkers in patients with mRCC.
FIALA, Ondrej; Katarina REJLEKOVA; Tomas BUCHLER; Hana STUDENTOVA; Alexandr POPRACH; Michal VOCKA; Petr HOSEK; Jindrich KOPECKY; Martin MATEJU; Anezka ZEMANKOVA; Martina SPISAROVA; Michaela TKADLECOVA; Peter PRIESTER; Jan KOURIL; Radka LOHYNSKA; Lucie GRMELOVA; Alexander SAVKA; Katarina STEFANIKOVA; Jana OBERTOVA; Dominika SIKOVA; Petr STRANSKY; Bohuslav MELICHAR a Patrik PALACKA. Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab. SCIENTIFIC REPORTS. England: NATURE PORTFOLIO, 2025, roč. 16, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-32593-8.
@article{101821, author = {Fiala, Ondrej and Rejlekova, Katarina and Buchler, Tomas and Studentova, Hana and Poprach, Alexandr and Vocka, Michal and Hosek, Petr and Kopecky, Jindrich and Mateju, Martin and Zemankova, Anezka and Spisarova, Martina and Tkadlecova, Michaela and Priester, Peter and Kouril, Jan and Lohynska, Radka and Grmelova, Lucie and Savka, Alexander and Stefanikova, Katarina and Obertova, Jana and Sikova, Dominika and Stransky, Petr and Melichar, Bohuslav and Palacka, Patrik}, article_location = {England}, article_number = {1}, doi = {https://doi.org/10.1038/s41598-025-32593-8}, keywords = {Renal cell carcinoma; Eosinophils; Neutrophil-to-eosinophil ratio; Immunotherapy; Nivolumab}, language = {eng}, issn = {2045-2322}, journal = {SCIENTIFIC REPORTS}, title = {Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab}, url = {https://www.nature.com/articles/s41598-025-32593-8}, volume = {16}, year = {2025} }
TY - JOUR ID - 101821 AU - Fiala, Ondrej - Rejlekova, Katarina - Buchler, Tomas - Studentova, Hana - Poprach, Alexandr - Vocka, Michal - Hosek, Petr - Kopecky, Jindrich - Mateju, Martin - Zemankova, Anezka - Spisarova, Martina - Tkadlecova, Michaela - Priester, Peter - Kouril, Jan - Lohynska, Radka - Grmelova, Lucie - Savka, Alexander - Stefanikova, Katarina - Obertova, Jana - Sikova, Dominika - Stransky, Petr - Melichar, Bohuslav - Palacka, Patrik PY - 2025 TI - Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab JF - SCIENTIFIC REPORTS VL - 16 IS - 1 SP - 1-12 EP - 1-12 PB - NATURE PORTFOLIO SN - 2045-2322 KW - Renal cell carcinoma KW - Eosinophils KW - Neutrophil-to-eosinophil ratio KW - Immunotherapy KW - Nivolumab UR - https://www.nature.com/articles/s41598-025-32593-8 N2 - lt; 65 (p = 0.025). The results of the present study suggest that eosinophil-based blood parameters including AEC and NER and their early dynamics during the course of treatment with nivolumab are promising and readily available prognostic biomarkers in patients with mRCC. ER -
FIALA, Ondrej; Katarina REJLEKOVA; Tomas BUCHLER; Hana STUDENTOVA; Alexandr POPRACH; Michal VOCKA; Petr HOSEK; Jindrich KOPECKY; Martin MATEJU; Anezka ZEMANKOVA; Martina SPISAROVA; Michaela TKADLECOVA; Peter PRIESTER; Jan KOURIL; Radka LOHYNSKA; Lucie GRMELOVA; Alexander SAVKA; Katarina STEFANIKOVA; Jana OBERTOVA; Dominika SIKOVA; Petr STRANSKY; Bohuslav MELICHAR a Patrik PALACKA. Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab. \textit{SCIENTIFIC REPORTS}. England: NATURE PORTFOLIO, 2025, roč.~16, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-32593-8.
